Dragunow M, Yamada N, Bilkey D K, Lawlor P
Department of Pharmacology, School of Medicine, University of Auckland, New Zealand.
Brain Res Mol Brain Res. 1992 Mar;13(1-2):119-26. doi: 10.1016/0169-328x(92)90051-c.
The expression of the protein products of the immediate-early genes c-fos, Fos B, Fos-related proteins (FRAs), c-jun, jun B, jun D and krox-24 was investigated in the rat hippocampus at various times after electrically-induced hippocampal seizures. Hippocampal seizures induced all the immediate-early gene proteins in dentate granule cells with differing time-courses. In addition, Krox-24, Fos and Jun D were also induced in somatostatin-containing interneurons throughout the hippocampus and also in a small percentage of parvalbumin-containing interneurons. Thus, hippocampal seizures induce waves of immediate-early gene protein expression in dentate granule cells and a selective expression of krox-24, Fos and Jun D in hippocampal somatostatin interneurons. These results suggest that biochemical and/or morphological changes occurring in dentate granule cells and somatostatin interneurons after seizures may be regulated by immediate-early gene expression, and that these immediate-early gene proteins may be involved in seizure development in the nervous system.
在电诱导海马癫痫发作后的不同时间，研究了即刻早期基因c-fos、Fos B、Fos相关蛋白（FRAs）、c-jun、jun B、jun D和krox-24的蛋白质产物在大鼠海马中的表达。海马癫痫发作在齿状颗粒细胞中诱导了所有即刻早期基因蛋白，且时间进程不同。此外，Krox-24、Fos和Jun D也在整个海马中含生长抑素的中间神经元以及一小部分含小白蛋白的中间神经元中被诱导。因此，海马癫痫发作在齿状颗粒细胞中诱导即刻早期基因蛋白表达浪潮，并在海马生长抑素中间神经元中选择性表达krox-24、Fos和Jun D。这些结果表明，癫痫发作后齿状颗粒细胞和生长抑素中间神经元中发生的生化和/或形态学变化可能受即刻早期基因表达调控，且这些即刻早期基因蛋白可能参与神经系统癫痫发作的发展。
