Riederer P, Lange K W, Kornhuber J, Danielczyk W
Department of Psychiatry, Clinical Neurochemistry, University of Würzburg, Fed. Rep. of Germay.
Arzneimittelforschung. 1992 Feb;42(2A):265-8.
Dopamine appears to be of less importance in the regulation of psychomotor functions than was previously thought. A central dopaminergic-glutamatergic balance may be important for both akinetic motor disorders and psychosis. In Parkinson's disease glutamate antagonists may counteract central glutamatergic hyperactivity and may be of value as anti-parkinsonian drugs. An increase of dopaminergic activity and/or a reduction of glutamatergic activity may contribute to the development of paranoid hallucinatory psychosis in schizophrenic patients and of pharmacotoxic psychosis in Parkinson's disease. Because of possibly severe side-effects of glutamatergic antagonists and agonists in the treatment of akinesia and psychosis, the development of partial glutamate agonists/antagonists could be an alternative strategy capable of producing antipsychotic or anti-kinetic effects with only mild adverse reaction.
多巴胺在调节精神运动功能方面的重要性似乎比之前认为的要低。中枢多巴胺能 - 谷氨酸能平衡对于运动不能性运动障碍和精神病可能都很重要。在帕金森病中，谷氨酸拮抗剂可能会抵消中枢谷氨酸能亢进，并且作为抗帕金森病药物可能具有价值。多巴胺能活性增加和/或谷氨酸能活性降低可能导致精神分裂症患者出现偏执性幻觉精神病以及帕金森病患者出现药物中毒性精神病。由于谷氨酸能拮抗剂和激动剂在治疗运动不能和精神病时可能会产生严重的副作用，开发部分谷氨酸激动剂/拮抗剂可能是一种替代策略，能够产生抗精神病或抗运动不能作用，且不良反应轻微。
