一部分药物治疗的精神分裂症患者中存在升高的IgG抗组蛋白抗体。

Elevated IgG anti-histone antibodies in a subgroup of medicated schizophrenic patients.

作者信息

Chengappa K N, Carpenter A B, Yang Z W, Brar J S, Rabin B S, Ganguli R

机构信息

Department of Psychiatry, Western Psychiatric Institute & Clinic, Pittsburgh, PA 15213-2593.

出版信息

Schizophr Res. 1992 Apr;7(1):49-54. doi: 10.1016/0920-9964(92)90073-e.

DOI:10.1016/0920-9964(92)90073-e

PMID:1350460

Abstract

A total of 57 schizophrenic patients (of which 17 were first-episode, neuroleptic naive) and 76 healthy controls were screened for anti-histone IgG antibodies using an enzyme immunoassay (ELISA). All patients had significantly higher anti-histone antibody titers than controls (t = 3.1, p less than 0.003). Previously medicated patients had significantly higher titers than neuroleptic-naive first episode patients (t = 2.87, p less than 0.006). This study suggests that neuroleptic medications are associated with anti-histone antibodies.

摘要

共有57名精神分裂症患者（其中17名是首次发作、未使用过抗精神病药物的患者）和76名健康对照者接受了酶免疫测定（ELISA）以检测抗组蛋白IgG抗体。所有患者的抗组蛋白抗体滴度均显著高于对照组（t = 3.1，p < 0.003）。曾接受过药物治疗的患者的滴度显著高于未使用过抗精神病药物的首次发作患者（t = 2.87，p < 0.006）。这项研究表明，抗精神病药物与抗组蛋白抗体有关。