左利手的首发、未使用过抗精神病药物的精神分裂症患者自身抗体的患病率较高。

Left-handed first-episode, neuroleptic-naive schizophrenic patients have a higher prevalence of autoantibodies.

作者信息

Chengappa K N, Ganguli R, Yang Z W, Brar J S, Li L, Rabin B S

机构信息

Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, PA 15213-2593.

出版信息

Schizophr Res. 1992 Oct;8(1):75-80. doi: 10.1016/0920-9964(92)90063-b.

DOI:10.1016/0920-9964(92)90063-b

PMID:1419935

Abstract

Using standard immunological techniques, sera from first-episode, neuroleptic-naive schizophrenic patients (n = 51) and age, race and sex matched healthy controls (n = 51) were screened for seven common autoantibodies. Significantly more left-handed (67%) than right-handed (23%) schizophrenic patients had autoantibodies (p = 0.011). Left-handed schizophrenic patients were six times more likely than right-handed patients or controls and four times more likely than left-handed controls to test positive for autoantibodies (p = 0.012). These data suggest that disease and sinistrality contribute to the excess of autoantibodies in schizophrenia.

摘要

运用标准免疫技术，对首发、未使用过抗精神病药物的精神分裂症患者（n = 51）以及年龄、种族和性别相匹配的健康对照者（n = 51）的血清进行七种常见自身抗体筛查。有自身抗体的精神分裂症患者中，左利手患者（67%）显著多于右利手患者（23%）（p = 0.011）。左利手精神分裂症患者检测出自身抗体呈阳性的可能性是右利手患者或对照者的六倍，是左利手对照者的四倍（p = 0.012）。这些数据表明，疾病和左利手共同导致了精神分裂症患者自身抗体过多。