Talasz H, Genser N, Mair J, Dworzak E A, Friedrich G, Moes N, Mühlberger V, Puschendorf B
Department of Medical Chemistry, University of Innsbruck Medical School, Austria.
Lancet. 1992 Jun 6;339(8806):1380-2. doi: 10.1016/0140-6736(92)91198-h.
Concentrations of creatine kinase (CK) MB mass and cardiac troponin T were measured in serial peripheral venous blood samples from 21 patients who underwent percutaneous transluminal coronary angioplasty (PTCA). Angiography showed side-branch occlusion during PTCA without clinical signs of myocardial injury in 5 patients. After PTCA, CKMB mass concentrations were substantially higher than normal in all 5 patients with side-branch occlusion, and troponin T concentrations were high in 3. By contrast, only 2 patients and 1 patient, respectively, without side-branch occlusion had slight rises in CKMB and troponin T. Release of the contractile protein troponin T reflects more severe damage to myocytes than simple leakage of CKMB. Therefore, myocardial damage induced by side-branch occlusion can be graded by measurement of troponin T in plasma.
对21例行经皮腔内冠状动脉成形术（PTCA）的患者，采集系列外周静脉血样本，测定其中肌酸激酶（CK）MB质量浓度和心肌肌钙蛋白T浓度。血管造影显示，5例患者在PTCA期间出现分支闭塞，但无心肌损伤的临床体征。PTCA后，所有5例分支闭塞患者的CKMB质量浓度均显著高于正常，3例患者的肌钙蛋白T浓度升高。相比之下，无分支闭塞的患者中，分别只有2例和1例的CKMB和肌钙蛋白T略有升高。收缩蛋白肌钙蛋白T的释放比CKMB的单纯渗漏反映出对心肌细胞更严重的损伤。因此，通过测量血浆中的肌钙蛋白T，可以对分支闭塞所致的心肌损伤进行分级。
