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常温或低温体外循环后的中枢神经系统功能障碍

Central-nervous-system dysfunction after warm or hypothermic cardiopulmonary bypass.

作者信息

Wong B I, McLean R F, Naylor C D, Snow W G, Harrington E M, Gawel M J, Woods R B, Fremes S E

机构信息

Department of Anaesthesia, Sunnybrook Health Centre, University of Toronto, Ontario, Canada.

出版信息

Lancet. 1992 Jun 6;339(8806):1383-4. doi: 10.1016/0140-6736(92)91200-r.

Abstract

The increasing popularity of warm heart surgery led us to assess the effect of temperature during cardiopulmonary bypass (CPB) on neuropsychological function after coronary surgery. 34 patients enrolled in a randomised trial of normothermic versus hypothermic CPB were subjected to a battery of psychomotor and memory tests before and after their operations. The mean nasopharyngeal temperature for warm CPB was 34.7 (SD 0.5) degrees C and that for hypothermic CPB was 27.8 (2.0) degrees C. In all seven neuropsychological tests the postoperative scores were better in the warm CPB than in the hypothermic group, although only one difference achieved significance (trial-making test A; p less than 0.023). Thus, neurological function after normothermic CPB seems to be no worse than that after hypothermic procedures.

摘要

心脏搭桥手术日益普及,促使我们评估体外循环(CPB)期间的温度对冠状动脉手术后神经心理功能的影响。34名参与常温与低温CPB随机试验的患者在手术前后接受了一系列心理运动和记忆测试。常温CPB的平均鼻咽温度为34.7(标准差0.5)摄氏度,低温CPB的平均鼻咽温度为27.8(2.0)摄氏度。在所有七项神经心理测试中,常温CPB组的术后得分均高于低温组,尽管只有一项差异具有统计学意义(A组连线测试;p<0.023)。因此,常温CPB后的神经功能似乎并不比低温手术后的神经功能差。

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