Heffron J J, Isaacs H
Klin Wochenschr. 1976 Sep 15;54(18):865-7. doi: 10.1007/BF01483587.
The presence of denervation-like changes and abnormal mitochondria in the muscle of carriers of the malignant hyperthermia syndrome suggest a neuropathic basis for the human syndrome. A defect in mitochondrial ATP synthesis resulting from denervation, and potentiated by some general anaesthetics, may be the primary muscle fibre lesion in the human malignant hyperthermic syndrome.
