Kreysel H W, Brügge P, Jänner M, Kimmig J
MMW Munch Med Wochenschr. 1976 Sep 24;118(39):1235-40.
The behavior of proteoglycanes was examined by histochemical methods in excised particles of skin from patients with progressive (n = 24) and circumscribed (n = 74) scleroderma. A method described by Ishikawa was principally used. An increase of the proteoglycanes was shown preferentially in the vascular and perivascular regions in progressive scleroderma and in the interfibrous space of the connective tissue in circumscribed scleroderma. While the vascular sclerosis is prominent from the clinical point of view in progressive scleroderma, the disease processes are found in collagen connective tissue of the corium in morphea.
采用组织化学方法，对进行性（n = 24）和局限性（n = 74）硬皮病患者切除的皮肤颗粒中的蛋白聚糖行为进行了研究。主要采用了石川描述的方法。在进行性硬皮病中，蛋白聚糖的增加主要出现在血管和血管周围区域；在局限性硬皮病中，则出现在结缔组织的纤维间间隙。从临床角度来看，进行性硬皮病中血管硬化较为突出，而硬斑病的病变过程则出现在真皮的胶原结缔组织中。
