血小板中5-羟色胺与三磷酸腺苷的关系。
The relationship between 5-hydroxytryptamine and adenosine triphosphate in blood platelets.
作者信息
BORN G V, INGRAM G I, STACEY R S
出版信息
Br J Pharmacol Chemother. 1958 Mar;13(1):62-4. doi: 10.1111/j.1476-5381.1958.tb00191.x.
Abstract
In normal platelets a proportionality was found between the amount of adenosine triphosphate (ATP) and amount of 5-hydroxytryptamine (5-HT) in platelets both before and after incubating them in plasma to which 5-HT had been added. In patients receiving reserpine and in others with myeloid leukaemia, the amount of 5-HT in the platelets and the uptake of 5-HT by them were depressed, while the amount of ATP was normal. The possibility that ATP is involved in the accumulation of 5-HT by platelets is discussed.
摘要
在正常血小板中，发现在向血浆中添加5-羟色胺（5-HT）前后，血小板中三磷酸腺苷（ATP）的量与5-HT的量之间存在比例关系。在接受利血平治疗的患者和其他患有髓性白血病的患者中，血小板中5-HT的量及其对5-HT的摄取均降低，而ATP的量正常。文中讨论了ATP参与血小板积累5-HT的可能性。
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本文引用的文献
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Reserpine and human platelet 5-hydroxytryptamine.利血平和人体血小板5-羟色胺
Experientia. 1956 Nov 15;12(11):424-5. doi: 10.1007/BF02157365.
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J Physiol. 1956 Sep 27;133(3):548-57. doi: 10.1113/jphysiol.1956.sp005607.
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5-Hydroxytryptamine in normal human platelets.正常人血小板中的5-羟色胺
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Determination of ATP and related compounds: firefly luminescence and other methods.ATP及相关化合物的测定：萤火虫发光法及其他方法。
Methods Biochem Anal. 1954;1:341-56. doi: 10.1002/9780470110171.ch13.
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