关于二磷酸腺苷、凝血酶和三乙基锡诱导血小板聚集的进一步观察
Further observations on platelet aggregation induced by adenosine diphosphate thrombin and tri-ethyl tin.
作者信息
O'brien J R
机构信息
Portsmouth and Isle of Wight Pathological Service.
出版信息
J Clin Pathol. 1963 May;16(3):223-6. doi: 10.1136/jcp.16.3.223.
Aggregation induced by adenosine diphosphate is inhibited by adenosine as well as by adenosine mono- and triphosphate. Thrombin-induced aggregation is also inhibited by adenosine and the monophosphate, but the triphosphate at a similar concentration is not inhibitory. Aggregation induced by tri-ethyl tin is accelerated by a critical concentration of triphosphate and delayed by a higher concentration. The tri-ethyl tin effect is inhibited by 5-hydroxytryptamine and by tryptamine. Platelets from patients treated with reserpine respond normally to these last two substances. Incubated platelets lose first their ability to respond normally to tri-ethyl tin, then to thrombin, and lastly to adenosine diphosphate. These results are briefly discussed.
二磷酸腺苷诱导的聚集受到腺苷以及一磷酸腺苷和三磷酸腺苷的抑制。凝血酶诱导的聚集也受到腺苷和一磷酸腺苷的抑制，但相同浓度的三磷酸腺苷却没有抑制作用。三乙锡诱导的聚集在临界浓度的三磷酸腺苷作用下加速，而在更高浓度下则延迟。三乙锡的作用受到5-羟色胺和色胺的抑制。用利血平治疗的患者的血小板对后两种物质反应正常。孵育后的血小板首先失去对三乙锡正常反应的能力，接着失去对凝血酶的反应能力，最后失去对二磷酸腺苷的反应能力。对这些结果进行了简要讨论。
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