白细胞介素-6受体在未经体外激活的血液淋巴细胞上的表达。
Expression of interleukin-6 receptor on blood lymphocytes without in vitro activation.
作者信息
Zola H, Flego L
机构信息
Department of Clinical Immunology, Flinders Medical Centre, South Australia.
出版信息
Immunology. 1992 Jun;76(2):338-40.
Abstract
A monoclonal antibody against the interleukin-6 receptor (IL-6R) has been used in a high-sensitivity immunofluorescence technique to study receptor expression on unstimulated blood lymphocytes. Most CD4 cells express IL-6 receptor, whilst a small and variable proportion of CD8 and B cells are positive. CD4+ cells express higher levels of receptor than CD8+ T cells, and CD45RO+ cells express higher levels than CD45RA cells.
摘要
一种抗白细胞介素-6受体（IL-6R）的单克隆抗体已被用于一种高灵敏度免疫荧光技术，以研究未受刺激的血液淋巴细胞上的受体表达。大多数CD4细胞表达IL-6受体，而一小部分且比例可变的CD8细胞和B细胞呈阳性。CD4+细胞比CD8+T细胞表达更高水平的受体，并且CD45RO+细胞比CD45RA细胞表达更高水平的受体。
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