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白细胞介素-6受体在未经体外激活的血液淋巴细胞上的表达。

Expression of interleukin-6 receptor on blood lymphocytes without in vitro activation.

作者信息

Zola H, Flego L

机构信息

Department of Clinical Immunology, Flinders Medical Centre, South Australia.

出版信息

Immunology. 1992 Jun;76(2):338-40.

PMID:1353064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1421523/
Abstract

A monoclonal antibody against the interleukin-6 receptor (IL-6R) has been used in a high-sensitivity immunofluorescence technique to study receptor expression on unstimulated blood lymphocytes. Most CD4 cells express IL-6 receptor, whilst a small and variable proportion of CD8 and B cells are positive. CD4+ cells express higher levels of receptor than CD8+ T cells, and CD45RO+ cells express higher levels than CD45RA cells.

摘要

一种抗白细胞介素-6受体（IL-6R）的单克隆抗体已被用于一种高灵敏度免疫荧光技术，以研究未受刺激的血液淋巴细胞上的受体表达。大多数CD4细胞表达IL-6受体，而一小部分且比例可变的CD8细胞和B细胞呈阳性。CD4+细胞比CD8+T细胞表达更高水平的受体，并且CD45RO+细胞比CD45RA细胞表达更高水平的受体。

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本文引用的文献

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Enhancement of the interleukin 2 receptor expression on T cells by multiple B-lymphotropic lymphokines.多种嗜B淋巴细胞因子增强T细胞上白细胞介素2受体的表达。
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Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies.利用单克隆抗体和多克隆抗体对白细胞介素-6受体表达进行表征。
J Immunol. 1989 Nov 1;143(9):2900-6.
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Circulating human T and B lymphocytes express the p55 interleukin-2 receptor molecule (TAC, CD25).循环中的人T淋巴细胞和B淋巴细胞表达p55白细胞介素-2受体分子（TAC，CD25）。
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A monoclonal antibody 7G7/B6, binds to an epitope on the human interleukin-2 (IL-2) receptor that is distinct from that recognized by IL-2 or anti-Tac.一种单克隆抗体7G7/B6，可与人白细胞介素-2（IL-2）受体上的一个表位结合，该表位与IL-2或抗Tac所识别的表位不同。
Hybridoma. 1985 Summer;4(2):91-102. doi: 10.1089/hyb.1985.4.91.
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Infection with HIV is associated with elevated IL-6 levels and production.感染HIV与白细胞介素-6水平升高及产生有关。
J Immunol. 1990 Jan 15;144(2):480-4.
9
Detection by immunofluorescence of surface molecules present in low copy numbers. High sensitivity staining and calibration of flow cytometer.通过免疫荧光检测低拷贝数存在的表面分子。高灵敏度染色及流式细胞仪校准。
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