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3-[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia.

作者信息

Hrib N J, Jurcak J G, Bregna D E, Dunn R W, Geyer H M, Hartman H B, Roehr J E, Rogers K L, Rush D K, Szczepanik A M

机构信息

Department of Chemical Research, Hoechst-Roussel Pharmaceuticals, Inc., Somerville, New Jersey 08876.

出版信息

J Med Chem. 1992 Jul 10;35(14):2712-5. doi: 10.1021/jm00092a024.

DOI:10.1021/jm00092a024
PMID:1353116
Abstract
摘要

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3-[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia.
J Med Chem. 1992 Jul 10;35(14):2712-5. doi: 10.1021/jm00092a024.
2
Metabolism of an atypical antipsychotic agent, 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2, 5,5-trimethyl-4-thiazolidinone (HP236).一种非典型抗精神病药物3-[4-[4-(6-氟苯并[b]噻吩-3-基)-1-哌嗪基]丁基]-2,5,5-三甲基-4-噻唑烷酮（HP236）的代谢
Drug Metab Dispos. 1996 Oct;24(10):1139-50.
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Structure-activity relationships of a series of novel (piperazinylbutyl)thiazolidinone antipsychotic agents related to 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate.一系列与3-[4-[4-(6-氟苯并[b]噻吩-3-基)-1-哌嗪基]丁基]-2,5,5-三甲基-4-噻唑烷酮马来酸盐相关的新型（哌嗪基丁基）噻唑烷酮类抗精神病药物的构效关系
J Med Chem. 1996 Sep 27;39(20):4044-57. doi: 10.1021/jm960268u.
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Differential serotoninergic and dopaminergic activities of the (R)- and the (S)-enantiomers of 2-(di-n-propylamino)tetralin.2-（二正丙基氨基）四氢萘的（R）-和（S）-对映体的5-羟色胺能和多巴胺能活性差异
Eur J Pharmacol. 1996 May 15;303(3):151-62. doi: 10.1016/0014-2999(96)00051-9.
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(+)-cis-8-Hydroxy-1-methyl-2-(di-n-propylamino)tetralin: a potent and highly stereoselective 5-hydroxytryptamine receptor agonist.（+）-顺式-8-羟基-1-甲基-2-（二正丙基氨基）四氢萘：一种强效且高度立体选择性的5-羟色胺受体激动剂。
J Med Chem. 1987 Nov;30(11):2105-9. doi: 10.1021/jm00394a029.
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Interactions of (+)- and (-)-8- and 7-hydroxy-2-(di-n-propylamino)tetralin at human (h)D3, hD2 and h serotonin1A receptors and their modulation of the activity of serotoninergic and dopaminergic neurones in rats.（+）-和（-）-8-及7-羟基-2-（二正丙基氨基）四氢萘与人（h）D3、hD2和h5-羟色胺1A受体的相互作用及其对大鼠5-羟色胺能和多巴胺能神经元活性的调节
J Pharmacol Exp Ther. 1997 Mar;280(3):1241-9.
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5-hydroxytryptamine (5-HT)1A receptors and the tail-flick response. I. 8-hydroxy-2-(di-n-propylamino) tetralin HBr-induced spontaneous tail-flicks in the rat as an in vivo model of 5-HT1A receptor-mediated activity.5-羟色胺（5-HT）1A受体与甩尾反应。I. 8-羟基-2-（二正丙基氨基）四氢萘溴化氢诱导大鼠自发甩尾作为5-HT1A受体介导活性的体内模型。
J Pharmacol Exp Ther. 1991 Mar;256(3):973-82.
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5-Hydroxy-2-methyl-2-(di-n-propylamino)tetralin: synthesis and central pharmacological effects.5-羟基-2-甲基-2-(二正丙基氨基)四氢萘：合成及其中枢药理作用
Acta Pharm Suec. 1985;22(2):65-74.
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8-Hydroxy-2-(di-n-propylamino)tetralin, a new centrally acting 5-hydroxytryptamine receptor agonist.8-羟基-2-（二正丙基氨基）四氢萘，一种新型中枢作用的5-羟色胺受体激动剂。
J Med Chem. 1981 Aug;24(8):921-3. doi: 10.1021/jm00140a002.
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