Genetic variation at fibrinogen loci and plasma fibrinogen levels. - Suppr | 超能文献

Genetic variation at fibrinogen loci and plasma fibrinogen levels.

作者信息

Connor J M, Fowkes F G, Wood J, Smith F B, Donnan P T, Lowe G D

机构信息

University Department of Medical Genetics, Duncan Guthrie Institute, Yorkhill, Glasgow.

出版信息

J Med Genet. 1992 Jul;29(7):480-2.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1016023/

Abstract

In view of the controversy regarding genetic variation at the fibrinogen loci and plasma fibrinogen levels, we have analysed DNA polymorphisms at the alpha (TaqI), beta (BclI and HaeIII), and gamma (KpnI/SacI) fibrinogen loci in 247 subjects whose plasma fibrinogen was determined by clotting and nephelometric assays. Strong linkage disequilibrium was found between the alpha/TaqI and gamma/KpnI/SacI markers and between the beta/BclI and beta/HaeIII markers. A lesser association was found between the alpha/TaqI and beta/BclI loci, beta/BclI and gamma/KpnI/SacI markers, alpha/TaqI and beta/HaeIII markers, and the gamma/KpnI/SacI and beta/HaeIII markers. This is consistent with the known physical order of these loci and suggests a relative excess of recombination in the alpha/gamma to beta interval. Plasma fibrinogen levels, by either assay method, when corrected or uncorrected for age, sex, and smoking habit, did not show any statistically significant associations with the four fibrinogen polymorphisms examined at the alpha, beta, and gamma fibrinogen loci either singly or when analysed as a haplotype.

摘要

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本文引用的文献

1

Nonuniform recombination within the human beta-globin gene cluster.

Am J Hum Genet. 1984 Nov;36(6):1239-58.

2

Plasma fibrinogen--a major coronary risk factor.

J R Coll Gen Pract. 1985 Dec;35(281):565-9.

3

Chromosomal localization of human and rat A alpha, B beta, and gamma fibrinogen genes by in situ hybridization.

Cytogenet Cell Genet. 1986;42(1-2):36-41. doi: 10.1159/000132248.

4

Sources of variability in coagulation factor assays.

Thromb Haemost. 1987 Dec 18;58(4):1073-7.

5

Evolution and organization of the fibrinogen locus on chromosome 4: gene duplication accompanied by transposition and inversion.

Proc Natl Acad Sci U S A. 1985 Apr;82(8):2344-8. doi: 10.1073/pnas.82.8.2344.

6

Role of genetic variation at the fibrinogen locus in determination of plasma fibrinogen concentrations.

Lancet. 1987 Jun 27;1(8548):1452-5. doi: 10.1016/s0140-6736(87)92205-7.

7

DNA polymorphisms at fibrinogen loci and plasma fibrinogen concentration.

Clin Genet. 1989 Oct;36(4):229-35. doi: 10.1111/j.1399-0004.1989.tb03195.x.

8

Plasma fibrinogen and coronary risk factors: the Scottish Heart Health Study.

J Clin Epidemiol. 1990;43(9):913-9. doi: 10.1016/0895-4356(90)90075-z.

9

Variation in the promoter region of the beta fibrinogen gene is associated with plasma fibrinogen levels in smokers and non-smokers.

Thromb Haemost. 1991 May 6;65(5):487-90.

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