Väisänen S, Rauramaa R, Penttilä I, Rankinen T, Gagnon J, Pérusse L, Chagnon M, Bouchard C
Kuopio Research Institute of Exercise Medicine, University of Kuopio, Finland.
Thromb Haemost. 1997 May;77(5):884-9.
We analyzed plasma fibrinogen level in relation to genetic polymorphisms in the alpha- and beta-fibrinogen gene loci. Furthermore, the association of other CVD risk markers with fibrinogen was studied twice, with a time interval of one year in 50 to 60 year old men (n = 183). DNA polymorphisms were detected by PCR and digestion with Taq I (alpha-fibrinogen), Hind III and Bcl I (beta-fibrinogen) restriction enzymes. The correlation coefficient between fibrinogen measurements was 0.48 (p < 0.001). Blood leucocytes and waist-to-hip circumference ratio were the strongest correlates of fibrinogen level in both examinations, and the changes in leucocyte count and plasma fibrinogen correlated positively (r = 0.40, p < 0.001). In Eastern Finnish men, the Taq I, Hind III or Bcl I restriction fragment length polymorphisms of the alpha- or beta-fibrinogen gene loci did not associate with fibrinogen level, either cross-sectionally or longitudinally.
我们分析了血浆纤维蛋白原水平与α-和β-纤维蛋白原基因位点遗传多态性的关系。此外，在50至60岁男性（n = 183）中，对其他心血管疾病风险标志物与纤维蛋白原的关联进行了两次研究，时间间隔为一年。通过聚合酶链反应（PCR）以及用Taq I（α-纤维蛋白原）、Hind III和Bcl I（β-纤维蛋白原）限制性内切酶消化来检测DNA多态性。纤维蛋白原测量值之间的相关系数为0.48（p < 0.001）。在两次检查中，血白细胞和腰臀围比都是与纤维蛋白原水平相关性最强的因素，白细胞计数变化与血浆纤维蛋白原呈正相关（r = 0.40，p < 0.001）。在芬兰东部男性中，α-或β-纤维蛋白原基因位点的Taq I、Hind III或Bcl I限制性片段长度多态性在横断面或纵向研究中均与纤维蛋白原水平无关。
