Ohashi H, Ichikawa A, Takagi N, Hotta T, Naoe T, Ohno R, Saito H
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Leukemia. 1992 Aug;6(8):859-62.
Sequential molecular and cellular changes during remission induction were investigated in a case of acute promyelocytic leukemia (APL) treated with all-trans-retinoic acid (ATRA). By means of clonality analysis, the assessment of the retinoic acid receptor alpha gene alterations, as well as conventional cytologic studies, it was demonstrated that remission induction of APL by ATRA proceeds in two steps: first, the differentiation of the leukemic clone to mature granulocytes and its subsequent extinction; second, proliferation/differentiation of the residual normal clones to restore polyclonal hematopoiesis.
在一例接受全反式维甲酸（ATRA）治疗的急性早幼粒细胞白血病（APL）患者中，研究了缓解诱导期间的一系列分子和细胞变化。通过克隆性分析、维甲酸受体α基因改变的评估以及传统细胞学研究，证实ATRA诱导APL缓解分两步进行：首先，白血病克隆分化为成熟粒细胞并随后消失；其次，残留正常克隆增殖/分化以恢复多克隆造血。
