类视黄醇对人白血病细胞系HL-60和NB4的诱导分化活性的相关性
Correlation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4.
作者信息
Hashimoto Y, Kagechika H, Kawachi E, Fukasawa H, Saito G, Shudo K
机构信息
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
出版信息
J Cancer Res Clin Oncol. 1995;121(11):696-8. doi: 10.1007/BF01218530.
Abstract
Retinoids, including all-trans-retinoic acid, its isomers, and fifty synthetic retinoids (retinobenzoic acids), were tested for differentiation-inducing activity on human leukemia cell lines HL-60 and NB4. A good linear correlation, with an r value of 0.91, between the ED50 values for the differentiation-inducing activity towards HL-60 cells and that towards NB4 cells was found.
摘要
对包括全反式维甲酸、其异构体以及五十种合成类视黄醇（视黄基苯甲酸）在内的类视黄醇，进行了对人白血病细胞系HL-60和NB4的诱导分化活性测试。发现对HL-60细胞的诱导分化活性的半数有效剂量（ED50）值与对NB4细胞的诱导分化活性的半数有效剂量值之间存在良好的线性相关性，相关系数r为0.91。
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