Monafo W W, Tandon S N, Ayvazian V H, Tuchschmidt J, Skinner A M, Deitz F
Surgery. 1976 Oct;80(4):465-73.
The wounds of 60 burned patients were treated topically with cerium nitrate, which was applied either as a cream or in aqueous solution. Cerium nitrate has a potent antiseptic effect in human burn wounds, especially against gram negative bacteria and fungi. Pseudomonas aeruginosa was recovered from the wounds infrequently and never predominated. Fungi were practically never found. No patient treated with cerium developed a necrotizing wound infection. Analysis of the detailed bacteriological data indicated that, in contrast to previous results with use of the nitrate or sulfadiazine salts of silver, when gram negative species predominated, the flora tended to be predominantly gram positive when cerium was used. Therefore, some patients were treated simultaneously with cerium nitrate and silver sulfadiazine; this resulted in an even more efficient suppression of the wound flora than was observed previously with either cerium alone or silver salts alone; results with the simultaneous topical therapy in patients with injuries that previously were uniformly lethal were excellent. No toxicity attributable to the use of cerium was observed, although one instance of methemoglobinemia due to nitrate was documented. The adsorption of topically applied cerium essentially is nil. The use of cerium nitrate was associated with a nearly 50 percent reduction in the anticipated death rate. Cerium nitrate is a promising new topical antiseptic agent for the treatment of burns, particularly when it is used in combination with silver sulfadiazine.
60名烧伤患者的伤口用硝酸铈进行局部治疗，硝酸铈以乳膏或水溶液的形式应用。硝酸铈对人类烧伤伤口有强大的抗菌作用，尤其对革兰氏阴性菌和真菌有效。从伤口中很少分离出铜绿假单胞菌，且该菌从未占主导地位。实际上从未发现真菌。接受硝酸铈治疗的患者均未发生坏死性伤口感染。对详细细菌学数据的分析表明，与先前使用硝酸银或磺胺嘧啶银盐的结果相反，当革兰氏阴性菌占主导时，使用铈时菌群往往以革兰氏阳性菌为主。因此，一些患者同时接受硝酸铈和磺胺嘧啶银治疗；这导致对伤口菌群的抑制比以前单独使用铈或单独使用银盐时更有效；在以前通常会致命的受伤患者中，同时进行局部治疗的效果极佳。未观察到因使用铈而产生的毒性，尽管记录了一例因硝酸盐导致的高铁血红蛋白血症。局部应用铈的吸附基本为零。使用硝酸铈使预期死亡率降低了近50%。硝酸铈是一种有前途的新型烧伤局部抗菌剂，特别是当它与磺胺嘧啶银联合使用时。
