Saffer L D, Rodeheaver G T, Hiebert J M, Edlich R F
Surg Gynecol Obstet. 1980 Aug;151(2):232-6.
The antimicrobial activity of cerium nitrate and silver sulfadiazine was assessed in vitro and in vivo using Pseudomonas aeruginosa. In vitro, the activity of silver sulfadiazine was significantly greater than that of cerium nitrate. Synergism between silver sulfadiazine and cerium nitrate was observed in water or saline solution suspensions, but not in broth. In vivo, cerium nitrate offered no therapeutic benefit in reducing wound infection in contaminated wounds. Treatment of similar wounds with silver sulfadiazine resulted in a significant decrease in wound infection and in the level of viable bacteria when compared with that for untreated controls. The addition of cerium nitrate to silver sulfadiazine in aqueous soultion reduced the therapeutic benefit of silver sulfadiazine.
使用铜绿假单胞菌在体外和体内评估了硝酸铈和磺胺嘧啶银的抗菌活性。在体外，磺胺嘧啶银的活性明显高于硝酸铈。在水或盐溶液悬浮液中观察到磺胺嘧啶银和硝酸铈之间有协同作用，但在肉汤中未观察到。在体内，硝酸铈在减少污染伤口的伤口感染方面没有治疗益处。与未治疗的对照组相比，用磺胺嘧啶银治疗类似伤口可显著降低伤口感染和活菌水平。在水溶液中向磺胺嘧啶银中添加硝酸铈降低了磺胺嘧啶银的治疗效果。
