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硝酸铈-磺胺嘧啶银乳膏治疗烧伤:一项前瞻性随机研究。

Cerium nitrate-silver sulfadiazine cream in the treatment of burns: a prospective, randomized study.

作者信息

Helvig E I, Munster A M, Su C T, Oppel W

出版信息

Am Surg. 1979 Apr;45(4):270-2.

PMID:434623
Abstract

In a prospective, randomized study of 34 patients with thermal burns, treatment with the topical agent Cerium nitrate-silver sulfadiazine was compared with therapy with silver sulfadiazine alone. Despite randomization, there was a significant difference in mean burn size, being larger in the silver sulfadiazine group. There was no significant difference between the two groups in clinical course, mortality, septic deaths, or quantitative microbiology of the burn wound. It is concluded that from these preliminary data no clearcut superiority for one cream over the other can be demonstrated at this time.

摘要

在一项针对34例热烧伤患者的前瞻性随机研究中,将局部用药硝酸铈 - 磺胺嘧啶银的治疗与仅使用磺胺嘧啶银的治疗进行了比较。尽管进行了随机分组,但平均烧伤面积存在显著差异,磺胺嘧啶银组的烧伤面积更大。两组在临床病程、死亡率、败血症死亡或烧伤创面的定量微生物学方面没有显著差异。结论是,根据这些初步数据,目前无法证明一种乳膏相对于另一种乳膏有明显的优越性。

相似文献

1
Cerium nitrate-silver sulfadiazine cream in the treatment of burns: a prospective, randomized study.硝酸铈-磺胺嘧啶银乳膏治疗烧伤:一项前瞻性随机研究。
Am Surg. 1979 Apr;45(4):270-2.
2
Cerium nitrate-silver sulfadiazine cream in the treatment of burns: a prospective evaluation.硝酸铈-磺胺嘧啶银乳膏治疗烧伤:一项前瞻性评估。
Surgery. 1980 Nov;88(5):658-60.
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Cerium nitrate: a new topical antiseptic for extensive burns.硝酸铈:一种用于大面积烧伤的新型局部抗菌剂。
Surgery. 1976 Oct;80(4):465-73.
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Our experience with the use of cerium sulphadiazine in the treatment of extensive burns.我们使用磺胺嘧啶铈治疗大面积烧伤的经验。
Acta Chir Plast. 1998;40(3):73-5.
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In vivo and in vitro antimicrobial activity of silver sulfadiazine and cerium nitrate.磺胺嘧啶银和硝酸铈的体内及体外抗菌活性
Surg Gynecol Obstet. 1980 Aug;151(2):232-6.
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[Determination of silver and cerium in the liver and the kidney from a severely burned infant treated with silver sulfadiazine and cerium nitrate].[用磺胺嘧啶银和硝酸铈治疗的重度烧伤婴儿肝脏和肾脏中银和铈的测定]
Radioisotopes. 1983 Feb;32(2):59-65.
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Burn wound sepsis: effect of delayed treatment with topical chemotherapy on survival.烧伤创面脓毒症:局部化疗延迟治疗对生存率的影响。
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Topical chemotherapy for burns using cerium salts and silver sulfadiazine.使用铈盐和磺胺嘧啶银进行烧伤的局部化疗。
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Comparison of silver sulfadiazine and gentamicin for topical prophylaxis against burn wound sepsis.磺胺嘧啶银与庆大霉素用于烧伤创面脓毒症局部预防的比较。
Can Med Assoc J. 1978 Sep 9;119(5):466-70.
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Bacteriological effect of cerium-flamazine cream in major burns.磺胺嘧啶铈乳膏对大面积烧伤的细菌学影响。
Burns Incl Therm Inj. 1985 Jun;11(5):337-42. doi: 10.1016/0305-4179(85)90096-8.

引用本文的文献

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Evaluation of silver sulfadiazine 1%-cerium nitrate 2.2% cream efficacy and safety in moderate to severe burn patients: a single-blind randomized clinical trial.1%磺胺嘧啶银-2.2%硝酸铈乳膏治疗中重度烧伤患者的疗效与安全性评估:一项单盲随机临床试验
Int J Burns Trauma. 2023 Oct 15;13(5):191-203. eCollection 2023.
2
The Use of Cerium Compounds as Antimicrobials for Biomedical Applications.铈化合物在生物医学应用中的抗菌作用。
Molecules. 2022 Apr 21;27(9):2678. doi: 10.3390/molecules27092678.
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Antiseptics for burns.烧伤用防腐剂
Cochrane Database Syst Rev. 2017 Jul 12;7(7):CD011821. doi: 10.1002/14651858.CD011821.pub2.
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Use of silver in the prevention and treatment of infections: silver review.银在感染预防和治疗中的应用:银的综述。
Surg Infect (Larchmt). 2013 Feb;14(1):8-20. doi: 10.1089/sur.2011.097. Epub 2013 Feb 28.
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[Experimental study of the local application of silver sulfadiazine, cefsulodin and povidone-iodine in burns].磺胺嘧啶银、头孢磺啶及聚维酮碘局部应用于烧伤的实验研究
Infection. 1984 Jan-Feb;12(1):31-5. doi: 10.1007/BF01641022.