Kahn E M, Munetz M R, Davies M A, Schulz S C
Department of Psychiatry, Dartmouth Medical School, Hanover, NH.
Compr Psychiatry. 1992 Jul-Aug;33(4):233-6. doi: 10.1016/0010-440x(92)90046-s.
Akathisia and tardive dyskinesia (TD) are disorders of movement that are often associated with administration of antipsychotic medication. We surveyed 196 outpatients in a schizophrenia clinic, all receiving antipsychotic medication, for the presence of these disorders. Clinical global ratings of akathisia were reliable. Akathisia was found in 36% of patients, and TD in 23.5%. Akathisia was disproportionately common in patients receiving high-potency neuroleptics. The data affirmed recent revisions in the dose-equivalence formulas used with fluphenazine decanoate. Akathisia and TD did not seem to be interrelated. Because akathisia is common and often limits medication dose and contributes to noncompliance, psychiatrists must take this into account when prescribing antipsychotic medication.
静坐不能和迟发性运动障碍（TD）是与抗精神病药物使用相关的运动障碍。我们对一家精神分裂症诊所的196名门诊患者进行了调查，这些患者均正在接受抗精神病药物治疗，以了解这些障碍的存在情况。对静坐不能的临床整体评定是可靠的。36%的患者存在静坐不能，23.5%的患者存在TD。在接受高效能抗精神病药物的患者中，静坐不能尤为常见。这些数据证实了最近对癸酸氟奋乃静使用的等效剂量公式所做的修订。静坐不能和TD似乎没有相关性。由于静坐不能很常见，且常常限制药物剂量并导致治疗依从性不佳，精神科医生在开具抗精神病药物处方时必须考虑到这一点。
