Dufresne R L, Wagner R L
Rhode Island Psychiatric Research and Training Center, Cranston 02920.
J Clin Psychiatry. 1988 Nov;49(11):435-8.
The authors present a study in which 33 chronic schizophrenic patients who, when withdrawn from antipsychotic drug treatment for more than 2 weeks, presented with concurrent signs of akathisia and tardive dyskinesia; however, signs of akinesia, facial masking, rigidity, or dystonia were not concurrent with the patients' akathetic presentation. In a subsequent study phase, these patients were treated with antipsychotics for up to 6 weeks. The dyskinetic signs that had been dramatically more severe in those patients exhibiting akathisia following withdrawal from antipsychotic medication continued for up to 6 weeks following the renewal of antipsychotic drug therapy. These findings help to confirm a relationship between tardive dyskinesia and a persistent akathisia of later onset known as tardive akathisia.
作者介绍了一项研究，该研究中有33名慢性精神分裂症患者，当他们停用抗精神病药物治疗超过2周时，同时出现了静坐不能和迟发性运动障碍的症状；然而，运动不能、面部表情缺失、僵硬或肌张力障碍的症状并未与患者的静坐不能表现同时出现。在随后的研究阶段，这些患者接受了长达6周的抗精神病药物治疗。在停用抗精神病药物后出现静坐不能的患者中，运动障碍症状在重新开始抗精神病药物治疗后的6周内持续显著加重。这些发现有助于证实迟发性运动障碍与一种后期出现的持续性静坐不能（称为迟发性静坐不能）之间的关系。
