Clausen I, Frost L, Børlum K G
Department of Gynecology and Obstetrics, Aarhus Kommunehospital, Denmark.
Int J Fertil. 1992 Jul-Aug;37(4):204-8.
In an 11-year period, 106 women were treated for two ectopic pregnancies (EP). Thirty-one had been surgically sterilized by the second operation. Of the 75 women with at least one patent tube, 70 (93%) were followed up regarding pregnancy outcome, with a mean follow-up period of 4.5 years. Fifty women had had a desire for pregnancy after treatment for the second EP. Of these, 26 (52%) did not achieve any conception; 16 (32%) experienced at least one more EP, and 13 (26%) had at least one intrauterine pregnancy. There were a total of 46 pregnancies, of which 21 (46%) were ectopic and 16 (35%) were carried on term. When conservative surgical techniques had been performed at the first EP, the number of intrauterine pregnancies achieved after the second EP was doubled, and the risk for a third EP was not raised. There was found no statistical difference in laterality of the second EP when the first operation was conservative. It is concluded that women experiencing repeat EP have severely impaired future fertility, with a high risk of a third EP if they conceive.
在11年期间，106名女性因两次异位妊娠（EP）接受治疗。其中31人在第二次手术时已接受手术绝育。在75名至少有一侧输卵管通畅的女性中，70人（93%）接受了妊娠结局随访，平均随访期为4.5年。50名女性在第二次异位妊娠治疗后有怀孕意愿。其中，26人（52%）未受孕；16人（32%）至少又经历了一次异位妊娠，13人（26%）至少有一次宫内妊娠。共有46次妊娠，其中21次（46%）为异位妊娠，16次（35%）足月分娩。当在首次异位妊娠时采用保守手术技术时，第二次异位妊娠后获得的宫内妊娠数量翻倍，且第三次异位妊娠的风险未增加。当首次手术为保守手术时，第二次异位妊娠的侧别未发现统计学差异。结论是，经历反复异位妊娠的女性未来生育能力严重受损，如果受孕，第三次异位妊娠的风险很高。
