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Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.

作者信息

Bloom J D, Dutia M D, Johnson B D, Wissner A, Burns M G, Largis E E, Dolan J A, Claus T H

机构信息

Medical Research Division, Lederle Laboratories, American Cyanamid Company, Pearl River, New York 10965.

出版信息

J Med Chem. 1992 Aug 7;35(16):3081-4. doi: 10.1021/jm00094a025.

DOI:10.1021/jm00094a025
PMID:1354264
Abstract
摘要

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1
Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.（R，R）-5-[2-[[2-（3-氯苯基）-2-羟乙基]氨基]丙基]-1，3-苯并二恶唑-2，2-二羧酸钠（CL 316,243）。一种几乎对β3受体具有特异性的强效β-肾上腺素能激动剂。一种有前景的抗糖尿病和抗肥胖药物。
J Med Chem. 1992 Aug 7;35(16):3081-4. doi: 10.1021/jm00094a025.
2
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3
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Improvement of metabolic disorders and visceral fat obesity by the beta 3-adrenoceptor agonist (R*,R*)-(+/-)-methyl-4-[2-[2-hydroxy-2 -(3-chlorophenyl)ethylamino]propyl]-phenoxyacetate hydrobromide (BRL35135A) in genetically obese rodents.β3-肾上腺素能受体激动剂（R*，R*）-（±）-甲基-4-[2-[2-羟基-2-（3-氯苯基）乙氨基]丙基]-苯氧基乙酸氢溴酸盐（BRL35135A）对遗传性肥胖啮齿动物代谢紊乱和内脏脂肪肥胖的改善作用
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