Shin Y S, Yoo E S, Min S K, Kim J R, Park K W
Department of Anesthesiology, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 1992 Mar;33(1):81-6. doi: 10.3349/ymj.1992.33.1.81.
The interaction between succinylcholine (SCC) and non-depolarizers, atracurium or vecuronium was investigated in 36 cats of either sex using the sciatic nerve-anterior tibialis muscle preparation. Additionally, the relation of SCC to pseudocholinesterase activity was examined. The duration of action of vecuronium (6.5 +/- 1.3 to 7.3 +/- 2.2 minutes) in cats pretreated with SCC was greater than those (2.0 +/- 0.6 minutes) in non-pretreated cats. However, SCC had no influence on the duration of atracurium. The serum pseudocholinesterase activity was decreased after the injection of atracurium or neostigmine in contrast to vecuronium. The authors conclude that the prior administration of SCC prolongs the duration of vecuronium but not that of atracurium, and pseudocholinesterase activity is not related to the prolonging effect of SCC.
使用坐骨神经-胫前肌标本，对36只雌雄不限的猫研究了琥珀酰胆碱（SCC）与非去极化肌松药阿曲库铵或维库溴铵之间的相互作用。此外，还研究了SCC与假性胆碱酯酶活性之间的关系。预先给予SCC的猫中维库溴铵的作用持续时间（6.5±1.3至7.3±2.2分钟）长于未预先给药的猫（2.0±0.6分钟）。然而，SCC对阿曲库铵的作用持续时间没有影响。与维库溴铵相比，注射阿曲库铵或新斯的明后血清假性胆碱酯酶活性降低。作者得出结论，预先给予SCC可延长维库溴铵的作用持续时间，但不能延长阿曲库铵的作用持续时间，且假性胆碱酯酶活性与SCC的延长作用无关。
