Miyamoto M, Hirai H, Fujimoto K, Yurino M, Ogawa H
Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical College.
Masui. 1994 Apr;43(4):487-91.
Effects of succinylcholine (SCC), 1 mg.kg-1, given following incomplete recovery from muscle paralysis induced by vecuronium were investigated in 27 female patients undergoing elective surgery, which was performed under epidural anesthesia. Anesthesia was induced with thiamylal 5 mg.kg-1 followed by SCC to facilitate orotracheal intubation. Vecuronium bromide 0.08 mg.kg-1 was given and the lungs were ventilated with 67% N2O in O2 and 0.6% sevoflurane. Neuromuscular function was monitored by means of the induced EMG. The ulnar nerve was stimulated at the wrist. Supramaximal trains of four stimuli (2 Hz for 2 s: pulse width 0.2 ms) were administered every 20 s. The effect of SCC varied depending upon the degree of recovery from vecuronium. At the 25% recovery point, the response to SCC was biphasic, showing an initial reversal followed by an increase of the partial vecuronium block which recovered showing a fade phenomenon on train-of-four stimulation. At the 50% recovery point, an initial reversal was slight. Administered at 75% recovery from vecuronium, SCC produced total neuromuscular blockade without initial recovery. The overall duration of the SCC effect (time from the administration to 90% recovery) was 7-18 min. No prolonged paralysis from SCC occurred.
在27例接受择期手术且采用硬膜外麻醉的女性患者中，研究了在维库溴铵诱导的肌肉麻痹未完全恢复后给予1mg·kg⁻¹琥珀酰胆碱（SCC）的效果。麻醉诱导采用5mg·kg⁻¹硫喷妥钠，随后给予SCC以利于经口气管插管。给予0.08mg·kg⁻¹溴化维库溴铵，并用67%氧化亚氮加氧气和0.6%七氟醚进行肺通气。通过诱发肌电图监测神经肌肉功能。在腕部刺激尺神经。每隔20秒给予一次超强的四个成串刺激（2Hz，持续2秒：脉冲宽度0.2毫秒）。SCC的效果因维库溴铵的恢复程度而异。在25%恢复点时，对SCC的反应呈双相，最初出现逆转，随后部分维库溴铵阻滞增加，四个成串刺激时恢复出现衰减现象。在50%恢复点时，最初的逆转轻微。在从维库溴铵恢复75%时给予SCC，可产生完全的神经肌肉阻滞，且无最初的恢复。SCC作用的总持续时间（从给药至90%恢复的时间）为7至18分钟。未发生SCC导致的长时间麻痹。
