Yau K I, Chien C H, Fong L L, Chen C L
Department of Pediatrics, College of Medicine, National Taiwan University, Taipei.
J Formos Med Assoc. 1992 Mar;91(3):287-93.
Breast milk jaundice (BMJ) is the most common etiology of prolonged unconjugated hyperbilirubinemia in a newborn infant. The pathogenesis of BMJ has been studied by many investigators, yet the etiology still remains uncertain. A prospective study was done to examine the role of breast milk beta-glucuronidase in BMJ in healthy full-term Chinese newborns. There were 71 infants in the formula-fed group (FF group), 28 in the breast-fed group (BF group) and 27 in the mixed feeding group (MF group). Study infants were followed at the well-baby clinic for at least two months. Enzyme activity in maternal breast milk and infants' stools decreased significantly during the first week postpartum. There was no intergroup difference in fecal enzyme activity for the different age groups. Significantly more infants in the BF group (35.7%) developed prolonged unconjugated hyperbilirubinemia than did infants in the FF group (2.8%) and the MF group (0%). We did not find higher enzyme activity in breast milk or stools of infants with BMJ than in infants without BMJ. We, therefore, conclude that breast milk beta-glucuronidase is not related to the development of BMJ.
母乳性黄疸（BMJ）是新生儿持续性非结合胆红素血症最常见的病因。许多研究者对BMJ的发病机制进行了研究，但其病因仍不明确。本研究旨在探讨母乳β-葡萄糖醛酸酶在健康足月中国新生儿BMJ中的作用。配方奶喂养组（FF组）71例婴儿，母乳喂养组（BF组）28例婴儿，混合喂养组（MF组）27例婴儿。研究婴儿在健康婴儿门诊随访至少两个月。产后第一周，母乳和婴儿粪便中的酶活性显著下降。不同年龄组的粪便酶活性无组间差异。BF组发生持续性非结合胆红素血症的婴儿（35.7%）显著多于FF组（2.8%）和MF组（0%）。我们未发现患BMJ婴儿的母乳或粪便中的酶活性高于未患BMJ的婴儿。因此，我们得出结论，母乳β-葡萄糖醛酸酶与BMJ的发生无关。
