[Age-related changes in mosquito insecticide resistance and their relation to the mechanisms of detoxication].

The mechanisms of DDT, permethrin and malathion resistance were determined indirectly by means of synergists inhibiting the detoxification enzymes. It was found that metabolic resistance dependent on glutathione-S-transferase, MFO and carboxylesterase is the most liable to age changes. Such changes are less expressive in mosquitos which have supposedly kdr-resistance. In young mosquitos (1-2 days) of all species, the rate of synergism is relatively low and fails to explain high resistance which is usual for juvenile specimen.