Sergieva V P, Gracheva G V
Med Parazitol (Mosk). 1992 Jan-Feb(1):11-5.
The mechanisms of DDT, permethrin and malathion resistance were determined indirectly by means of synergists inhibiting the detoxification enzymes. It was found that metabolic resistance dependent on glutathione-S-transferase, MFO and carboxylesterase is the most liable to age changes. Such changes are less expressive in mosquitos which have supposedly kdr-resistance. In young mosquitos (1-2 days) of all species, the rate of synergism is relatively low and fails to explain high resistance which is usual for juvenile specimen.
通过增效剂抑制解毒酶间接确定了对滴滴涕、氯菊酯和马拉硫磷的抗性机制。结果发现，依赖谷胱甘肽-S-转移酶、多功能氧化酶和羧酸酯酶的代谢抗性最容易随年龄变化。在假定具有击倒抗性的蚊子中，这种变化表现得不太明显。在所有物种的幼蚊（1-2日龄）中，增效作用的速率相对较低，无法解释幼蚊样本通常具有的高抗性。
