Friston K J, Grasby P M, Bench C J, Frith C D, Cowen P J, Liddle P F, Frackowiak R S, Dolan R
MRC Cyclotron Unit, Hammersmith Hospital, London, UK.
Neurosci Lett. 1992 Jul 6;141(1):106-10. doi: 10.1016/0304-3940(92)90345-8.
Cognitive activation in conjunction with pharmacological challenge was used to demonstrate neuromodulation in man. Using positron emission tomography (PET), measurements of regional cerebral blood flow were made during the performance of memory tasks, before and after the administration of apomorphine (dopamine agonist), buspirone (5-HT1A partial agonist) or placebo. Drug effects on memory-induced increases in regional cerebral blood flow were assessed, on a voxel-by-voxel basis, using statistical parametric mapping. Increases of regional cerebral blood flow in response to the memory challenge were attenuated by apomorphine in the dorsolateral prefrontal cortex and augmented in the retrosplenial region of the posterior cingulate. Conversely, buspirone attenuated blood flow increases in the retrosplenial region. These interactions between drugs and a cognitive challenge can best be interpreted as neuromodulatory effects.
认知激活与药理学激发相结合被用于证明人类的神经调节作用。使用正电子发射断层扫描（PET），在记忆任务执行期间、给予阿扑吗啡（多巴胺激动剂）、丁螺环酮（5-HT1A部分激动剂）或安慰剂之前及之后，对局部脑血流进行测量。使用统计参数映射在逐个体素的基础上评估药物对记忆诱导的局部脑血流增加的影响。阿扑吗啡使背外侧前额叶皮质中对记忆激发的局部脑血流增加减弱，而在后扣带回的压后皮质区域增强。相反，丁螺环酮减弱了压后皮质区域的血流增加。药物与认知激发之间的这些相互作用最好被解释为神经调节作用。
