Grasby P M, Friston K J, Bench C J, Cowen P J, Frith C D, Liddle P F, Frackowiak R S, Dolan R J
MRC Cyclotron Unit, Hammersmith Hospital, London.
Psychol Med. 1993 Aug;23(3):605-12. doi: 10.1017/s0033291700025381.
Apomorphine, a non-selective dopamine agonist, has been used as a pharmacological probe for investigating central dopaminergic neurotransmission in psychiatric illness. In this study repeated measurements of regional cerebral blood flow (rCBF) were made in normal volunteers before, and after, the administration of apomorphine (5 or 10 micrograms/kg), or placebo. The difference in rCBF, before and after drug (apomorphine versus placebo), was used to identify brain areas affected by apomorphine. Compared to placebo, both doses of apomorphine increased blood flow in the anterior cingulate cortex. Apomorphine 10 micrograms/kg also increased prefrontal rCBF (right > left). No decreases in rCBF were noted following either dose of apomorphine. Apomorphine-induced increases of anterior cingulate blood flow might serve as an in vivo index of central dopamine function. Such an approach would complement established neuroendocrine challenge paradigms for investigating central dopamine neurotransmission in psychiatric illness.
阿扑吗啡是一种非选择性多巴胺激动剂，已被用作药理学探针，用于研究精神疾病中的中枢多巴胺能神经传递。在本研究中，对正常志愿者在给予阿扑吗啡（5或10微克/千克）或安慰剂之前和之后进行了多次局部脑血流量（rCBF）测量。药物（阿扑吗啡与安慰剂）前后rCBF的差异用于确定受阿扑吗啡影响的脑区。与安慰剂相比，两种剂量的阿扑吗啡均增加了前扣带回皮质的血流量。10微克/千克的阿扑吗啡还增加了前额叶rCBF（右侧>左侧）。两种剂量的阿扑吗啡后均未观察到rCBF降低。阿扑吗啡引起的前扣带回血流量增加可能作为中枢多巴胺功能的体内指标。这种方法将补充既定的神经内分泌激发范式，用于研究精神疾病中的中枢多巴胺神经传递。
