编码肝细胞核因子1（HNF1）的基因结构。
Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1).
作者信息
Bach I, Pontoglio M, Yaniv M
机构信息
UA 1149 du CNRS, Département des Biotechnologies, Institut Pasteur, Paris, France.
出版信息
Nucleic Acids Res. 1992 Aug 25;20(16):4199-204. doi: 10.1093/nar/20.16.4199.
Abstract
Genomic clones have been isolated that cover the entire gene for the transcription factor HNF1 (hepatocyte nuclear factor 1). This protein governs the expression of many genes, synthesized in the liver in a tissue-specific manner. We have determined the intron/exon structure of the HNF1 gene, which is strictly conserved between rat and mouse and estimate that it spans not more than 40kb in the rat genome. Whereas most homeoprotein genes do not contain introns within the homeodomain, HNF1 displays an intron between the regions encoding the second and the third helices. We discuss possible evolutionary mechanisms leading to this homeobox intron/exon pattern.
摘要
已经分离出覆盖转录因子HNF1（肝细胞核因子1）整个基因的基因组克隆。这种蛋白质控制着许多基因的表达，在肝脏中以组织特异性方式合成。我们已经确定了HNF1基因的内含子/外显子结构，该结构在大鼠和小鼠之间严格保守，估计在大鼠基因组中跨度不超过40kb。虽然大多数同源异型蛋白基因在同源结构域内不包含内含子，但HNF1在编码第二和第三螺旋的区域之间显示出一个内含子。我们讨论了导致这种同源异型框内含子/外显子模式的可能进化机制。
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