Pulce C, Mollon P, Pham E, Frantz P, Descotes J
Service de Pharmaco-Toxicovigilance, Hospital E. Herriot, Lyon, France.
Vet Hum Toxicol. 1992 Apr;34(2):141-3.
Even though acute poisonings with benzodiazepines are extremely common, less is known of the clinical toxicity of recent derivatives, particularly in children. 1,989 cases involving ethyle loflazepate, flunitrazepam, prazepam or triazolam recorded at the Lyons Poison Center and due to 1 compound and associated with clinical symptoms were selected for study. Children less than 16-y of age accounted for 482 cases. Sleepiness, agitation and ataxia were significantly more frequent in the children. Hypotonia was seldom observed but was indicative of severe poisoning. The dangerous toxic dose of these compounds in children is suggested to be 0.78-0.90 mg ethyle loflazepate/kg, 0.26-0.29 mg flunitrazepam/kg, 7.80-9.00 mg prazepam/kg and 0.06-0.07 mg triazolam/kg. These results are in keeping with the relatively low acute toxicity of the older benzodiazepines.
尽管苯二氮䓬类药物急性中毒极为常见，但对于近期衍生物的临床毒性，尤其是儿童中的情况，人们了解较少。从里昂中毒中心记录的1989例涉及乙基氯氮䓬、氟硝西泮、普拉西泮或三唑仑的病例中，选取因单一化合物中毒且伴有临床症状的病例进行研究。16岁以下儿童占482例。嗜睡、烦躁和共济失调在儿童中明显更为常见。肌张力减退很少观察到，但提示严重中毒。这些化合物在儿童中的危险中毒剂量建议为乙基氯氮䓬0.78 - 0.90毫克/千克、氟硝西泮0.26 - 0.29毫克/千克、普拉西泮7.80 - 9.00毫克/千克和三唑仑0.06 - 0.07毫克/千克。这些结果与较老的苯二氮䓬类药物相对较低的急性毒性相符。
