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血液干细胞移植已走向成熟。

Blood stem cell transplants come of age.

作者信息

Gale R P, Henon P, Juttner C

机构信息

Department of Medicine, UCLA School of Medicine 90024-1678.

出版信息

Bone Marrow Transplant. 1992 Mar;9(3):151-5.

PMID:1354993
Abstract

In this report we review meeting highlights. Clearly there has been substantial progress in the laboratory and clinic with regard to blood stem cells. Having proven that these transplants work, it is now time to investigate biologic features in greater detail. Also needed are randomized trials evaluating several of the issues we raise such as whether the better results of blood cell autotransplants are due to more effective treatment or subject selection and whether in vitro removal of tumor cells is necessary or effective.

摘要

在本报告中,我们回顾了会议要点。显然,在血液干细胞的实验室研究和临床应用方面已经取得了重大进展。既然已经证明这些移植是有效的,现在是时候更详细地研究其生物学特性了。还需要进行随机试验,以评估我们提出的几个问题,例如血细胞自体移植效果更好是由于治疗更有效还是受试者选择的原因,以及体外清除肿瘤细胞是否必要或有效。

相似文献

1
Blood stem cell transplants come of age.血液干细胞移植已走向成熟。
Bone Marrow Transplant. 1992 Mar;9(3):151-5.
2
Comparison of haematological recovery times and supportive care requirements of autologous recovery phase peripheral blood stem cell transplants, autologous bone marrow transplants and allogeneic bone marrow transplants.自体恢复期外周血干细胞移植、自体骨髓移植和异基因骨髓移植的血液学恢复时间及支持性护理需求比较。
Bone Marrow Transplant. 1992 Apr;9(4):277-84.
3
Autologous and allogeneic transplantation with peripheral blood stem cells.自体及异体外周血干细胞移植。
Prog Clin Biol Res. 1992;377:603-10; discussion 611-3.
4
What's new in blood progenitor cell autotransplants?
Bone Marrow Transplant. 1994 Sep;14(3):343-6.
5
Blood and marrow transplantation activity in Europe 1996. European Group for Blood and Marrow Transplantation (EBMT).1996年欧洲的血液和骨髓移植活动。欧洲血液和骨髓移植组(EBMT)。
Bone Marrow Transplant. 1998 Aug;22(3):227-40. doi: 10.1038/sj.bmt.1701329.
6
Indications and donor source of hematopoietic stem cell transplants in Europe 1993: report from the European Group for Blood and Marrow Transplantation (EBMT).1993年欧洲造血干细胞移植的适应证与供者来源:欧洲血液与骨髓移植组(EBMT)报告
Clin Transplant. 1995 Oct;9(5):355-63.
7
The biology and clinical uses of blood stem cells.
Blood. 1997 Apr 1;89(7):2233-58.
8
Mononuclear and CD34+ stem cell recovery after automated Ficoll processing of marrow or peripheral blood stem cells for transplantation.用于移植的骨髓或外周血干细胞经自动Ficoll处理后单核细胞和CD34+干细胞的恢复情况。
Prog Clin Biol Res. 1992;377:569-73.
9
Autologous blood stem cell versus bone marrow transplantation.自体血干细胞移植与骨髓移植
Bone Marrow Transplant. 1992;10 Suppl 1:144-8.
10
Hematopoietic stem cells. Animal models and human transplantation. Introduction.
Curr Top Microbiol Immunol. 1992;177:xi-xiii.

引用本文的文献

1
Effect of alternating combination chemotherapy consisting of cyclophosphamide, doxorubicin, vincristine, cisplatin, and etoposide for small cell lung cancer on hematopoietic progenitors in the peripheral blood.环磷酰胺、阿霉素、长春新碱、顺铂和依托泊苷交替联合化疗对小细胞肺癌患者外周血造血祖细胞的影响
Br J Cancer. 1993 Apr;67(4):798-800. doi: 10.1038/bjc.1993.145.
2
Frozen vs. nonfrozen bone marrow for autologous transplantation in lymphomas: a report from the Spanish GEL/TAMO Cooperative Group.冷冻与非冷冻骨髓用于淋巴瘤自体移植:西班牙GEL/TAMO合作组的报告
Ann Hematol. 1993 Sep;67(3):111-4. doi: 10.1007/BF01701731.
3
Autografting with blood progenitor cells: predictive value of preapheresis blood cell counts on progenitor cell harvest and correlation of the reinfused cell dose with hematopoietic reconstitution.
血液祖细胞自体移植:采集前血细胞计数对祖细胞收获量的预测价值以及回输细胞剂量与造血重建的相关性。
Ann Hematol. 1995 Nov;71(5):227-34. doi: 10.1007/BF01744372.