Rodríguez-Sánchez M N, Arilla E
Department of Biochemistry and Molecular Biology, Medical School, University of Alcalá, Madrid, Spain.
Brain Res. 1992 Jul 17;586(1):67-71. doi: 10.1016/0006-8993(92)91372-l.
The effects of chronic prenatal and/or postnatal exposure to cocaine on somatostatin concentration and receptors were studied in the olfactory bulbs of rat pups at birth and at 15 days old. Wistar rats were injected subcutaneously with single daily doses of 40 mg cocaine hydrochloride/kg from days 7 to 19 of gestation, from day 7 of gestation to day 15 postpartum or from parturation to day 15 postpartum. Fetal exposure to cocaine decreased SS concentrations in the olfactory bulb of the newborn pups while prenatal-plus-postnatal exposure increased this parameter. Administration of cocaine only during lactation did not induce any change. Exposure during gestation or during nursing induced an increase in the total number of somatostatin receptors and a decrease in the affinity constant in the olfactory bulb of newborn and 15-day-old pups. These results suggest that the development of somatostatin receptors in the olfactory bulb can be altered by prenatal and/or nursing period exposure to cocaine.
研究了产前和/或产后长期暴露于可卡因对新生和15日龄大鼠幼崽嗅球中生长抑素浓度及受体的影响。将Wistar大鼠从妊娠第7天至第19天、从妊娠第7天至产后第15天或从分娩至产后第15天，每天皮下注射40毫克盐酸可卡因/千克。胎儿期暴露于可卡因会降低新生幼崽嗅球中的生长抑素浓度，而产前加产后暴露则会增加该参数。仅在哺乳期给予可卡因未引起任何变化。妊娠期间或哺乳期暴露会导致新生和15日龄幼崽嗅球中生长抑素受体总数增加，亲和常数降低。这些结果表明，产前和/或哺乳期暴露于可卡因可改变嗅球中生长抑素受体的发育。
