Rodriguez-Sanchez M N, Arilla E
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Alcala, Madrid, Spain.
Neuropeptides. 1990 May;16(1):1-7. doi: 10.1016/0143-4179(90)90022-q.
The effects of acute and chronic cocaine (40 mg/Kg i.p.) in vivo administration, on 125I-Tyr11-somatostatin binding and somatostatin-like immunoreactivity (SLI) in the rat frontoparietal cortex, hippocampus and olfactory bulb were explored. Acute and chronic cocaine administration did not affect the levels of SLI in the three brain areas studied. Acute cocaine administration resulted in an 55% and 32% decrease in the total number of specific somatostatin receptors in the hippocampus and olfactory bulb respectively, but not in the frontoparietal cortex. Somatostatin receptor affinity increased in the hippocampus and was unaltered in frontoparietal cortex and olfactory bulb. After two weeks of daily cocaine injections the somatostatin binding in the hippocampus and olfactory bulb returned to control values. The in vitro addition of cocaine to a brain membrane preparation obtained from untreated rats did not markedly affect somatostatin binding characteristics. These results are suggestive of a possible role for somatostatin in the limbic structures as a response to cocaine administration.
研究了急性和慢性腹腔注射可卡因（40毫克/千克）对大鼠额顶叶皮质、海马体和嗅球中125I-酪氨酸11-生长抑素结合及生长抑素样免疫反应性（SLI）的影响。急性和慢性可卡因给药对所研究的三个脑区的SLI水平没有影响。急性可卡因给药分别导致海马体和嗅球中特异性生长抑素受体总数减少55%和32%，但额顶叶皮质未受影响。海马体中生长抑素受体亲和力增加，而额顶叶皮质和嗅球中未发生改变。在每天注射可卡因两周后，海马体和嗅球中的生长抑素结合恢复到对照值。在体外将可卡因添加到从未经处理的大鼠获得的脑膜制剂中，并未显著影响生长抑素结合特性。这些结果表明，生长抑素在边缘结构中可能作为对可卡因给药的一种反应发挥作用。
