Carrieri P B, Indaco A, Maiorino A, Buscaino G A, Ponticiello A, Liberti A, Perrella O
Institute of Neurology, 2nd Medical School, University of Naples, Italy.
Neurol Res. 1992 Jun;14(3):282-3. doi: 10.1080/01616412.1992.11740070.
Cerebrospinal fluid (CSF) and serum concentrations of beta-2-microglobulin (beta-2-m) were evaluated in 19 patients with clinically definite multiple sclerosis (MS), in 21 with AIDS dementia complex (ADC), and in 20 subjects with other neurological diseases (OND). CSF beta-2-m and CSF/serum beta-2-m ratio were significantly higher in the patients with ADC than in the MS and OND patients. The CSF and serum levels of beta-2-m in MS patients were not significantly different from those of OND patients. These findings indicate that CSF beta-2-m and CSF/serum ratio may be a useful marker in the diagnosis of ADC. In MS patients the beta-2-m CSF determinations are of no value.
对19例临床确诊的多发性硬化症（MS）患者、21例艾滋病痴呆综合征（ADC）患者以及20例患有其他神经系统疾病（OND）的受试者，评估了脑脊液（CSF）和血清中β2-微球蛋白（β2-m）的浓度。ADC患者的脑脊液β2-m和脑脊液/血清β2-m比值显著高于MS患者和OND患者。MS患者的脑脊液和血清β2-m水平与OND患者无显著差异。这些发现表明，脑脊液β2-m和脑脊液/血清比值可能是诊断ADC的有用标志物。在MS患者中，脑脊液β2-m测定无价值。
