Us O, Lolli F, Baig S, Link H
Department of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Acta Neurol Scand. 1989 Dec;80(6):598-602. doi: 10.1111/j.1600-0404.1989.tb03934.x.
Beta-2-microglobulin (beta 2m) levels were studied in the cerebrospinal fluid (CSF) and plasma of 52 patients with clinically definite multiple sclerosis (MS) and of 14 with aseptic meningo-encephalitis (AM). Reference values for beta 2m were defined in 72 subjects of different age groups with tension headache (TH). Plasma levels of beta 2m increased with age in TH controls, particularly in the older age group, while no significant age variation could be detected for CSF beta 2m. Increased levels of beta 2m were found in the CSF and plasma of AM patients and in the CSF in MS. Calculations of CSF/plasma beta 2m ratios showed higher values in AM, reflecting intrathecal beta 2m synthesis, while only borderline alterations were evident in MS. Demonstration of intrathecal production of beta 2m is an additional CSF finding that may be useful in evaluating, among others, inflammatory nervous system disorders, but it has limited importance in the study of MS patients.
对52例临床确诊的多发性硬化症（MS）患者和14例无菌性脑膜脑炎（AM）患者的脑脊液（CSF）和血浆中的β2-微球蛋白（β2m）水平进行了研究。在72名患有紧张性头痛（TH）的不同年龄组受试者中确定了β2m的参考值。在TH对照组中，血浆β2m水平随年龄增加，尤其是在老年组，而CSFβ2m未发现明显的年龄差异。在AM患者的CSF和血浆以及MS患者的CSF中发现β2m水平升高。CSF/血浆β2m比值的计算显示AM患者的值更高，反映了鞘内β2m的合成，而MS患者仅表现为临界改变。鞘内β2m产生的证明是CSF的另一项发现，这可能有助于评估炎症性神经系统疾病等，但在MS患者的研究中其重要性有限。
