Prigent S A, Lemoine N R
Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
Prog Growth Factor Res. 1992;4(1):1-24. doi: 10.1016/0955-2235(92)90002-y.
This review considers the biology of the type 1 growth factor receptor family which is increasingly recognised as important in the control of normal cell proliferation and in the pathogenesis of human cancer. The family currently comprises three closely related members: the epidermal growth factor (EGF) receptor, c-erbB-2 and c-erbB-3, all of which show abnormalities of expression in various human tumours. The family of factors related to EGF has also expanded recently and now includes transforming growth factor alpha, heparin-binding EGF, amphiregulin, cripto and heregulin, as well as several other potential ligands for the c-erbB2-2 receptor. The involvement of these receptors and growth factors in human cancer has implications for the design of novel forms of therapy for cancer, and we review recent advances and future avenues for investigation.
本综述探讨了1型生长因子受体家族的生物学特性，该家族在正常细胞增殖调控及人类癌症发病机制中的重要性日益受到认可。该家族目前包含三个密切相关的成员：表皮生长因子（EGF）受体、c-erbB-2和c-erbB-3，它们在各种人类肿瘤中均表现出表达异常。与EGF相关的因子家族最近也有所扩展，目前包括转化生长因子α、肝素结合EGF、双调蛋白、cripto和神经调节蛋白，以及c-erbB2-2受体的其他几种潜在配体。这些受体和生长因子在人类癌症中的作用为新型癌症治疗方法的设计提供了思路，我们将综述近期的进展以及未来的研究方向。
