Utsunomiya A, Kuwazuru Y, Chuman Y, Mishige Y, Saito T, Terada A, Iwahashi M, Hanada S, Yoshimura A, Akiyama S
Second Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Japan.
Gan To Kagaku Ryoho. 1992 Sep;19(11):1915-8.
A 55-year-old woman with chronic myelogenous leukemia developed a lymphoid blast crisis (BC) 10 months after diagnosis. By using immunoblotting with a monoclonal antibody against P-glycoprotein (P-gp) C219, her leukemia cells from the first and 3rd crises were shown to be negative for the P-gp, while the cells of the 4th crisis were detected to have a high level of P-gp. This patient did not respond to chemotherapy with several anti-cancer agents in the 4th crisis, although complete remission was achieved in the first, second and third crises after administration of agents including vincristine and prednisolone. Therefore the expression of P-gp in the 4th BC might have been closely related to the resistance to chemotherapy.
一名55岁的慢性粒细胞白血病女性患者在诊断后10个月发生了淋巴母细胞危象（BC）。通过使用抗P-糖蛋白（P-gp）C219单克隆抗体进行免疫印迹分析，发现其第一次和第三次危象时的白血病细胞P-gp呈阴性，而第四次危象时的细胞检测到高水平的P-gp。该患者在第四次危象时对几种抗癌药物化疗无反应，尽管在使用长春新碱和泼尼松龙等药物后，第一次、第二次和第三次危象时达到了完全缓解。因此，第四次BC中P-gp的表达可能与化疗耐药密切相关。
