Expression of a multidrug resistance gene in blast crisis of chronic myelogenous leukemia.
作者信息
Pirker R, Goldstein L J, Ludwig H, Linkesch W, Lechner C, Gottesman M M, Pastan I
机构信息
First Medical Clinic, University of Vienna Medical School, Austria.
出版信息
Cancer Commun. 1989;1(2):141-4. doi: 10.3727/095535489820875354.
PMID:2639725
Abstract
Three of four patients with chronic myelogenous leukemia in blast crisis were found to express the multidrug resistance (MDR1) gene in their blast cells. Expression of the MDR1 gene may contribute to the poor response of these patients to chemotherapy.
摘要
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