de Gandarias J M, Casis O, Echevarría E, Irazusta J, Casis L
Department of Physiology, School of Medicine and Dentistry, University of the Basque Country, Leioa, Spain.
Int J Dev Biol. 1992 Jun;36(2):335-7.
Thyrotropin Releasing Hormone (TRH) is a principal regulator of thyroid system function. However, significant concentrations of TRH were found throughout the central nervous system, the cortex being one of the areas most richly endowed with thyroliberin. Research concerning the functional role of this brain peptide is performed, in part, by studying peptidase enzymes which may be involved in the inactivation of the peptide. The pGlu-His bond is cleaved by two pyroGlu-peptidases: I (soluble) and II (membrane-bound). In the present investigation, developmental activity of the soluble form is described in the cortices of the cat brain. The selected maturation stages were 15 and 30 days postnatal. The cortices were the frontal, parietal, area 17 and areas 18 and 19 as a whole, distinguishing brain hemispheres in all cases. PyroGlu-aminopeptidase I activity increased significantly with age in all the brain regions except area 17. It is suggested that this enzyme activity plays a part in the neurochemical changes that take place during brain maturation.
促甲状腺激素释放激素（TRH）是甲状腺系统功能的主要调节因子。然而，在整个中枢神经系统中都发现了高浓度的TRH，皮质是甲状腺释放素含量最丰富的区域之一。关于这种脑肽功能作用的研究，部分是通过研究可能参与该肽失活的肽酶来进行的。pGlu-His键可被两种焦谷氨酸肽酶裂解：酶I（可溶性）和酶II（膜结合）。在本研究中，描述了猫脑皮质中可溶性形式的发育活性。选定的成熟阶段为出生后15天和30天。皮质包括额叶、顶叶、17区以及整个18区和19区，所有情况下均区分脑半球。除17区外，所有脑区的焦谷氨酸氨肽酶I活性均随年龄显著增加。提示该酶活性在脑成熟过程中发生的神经化学变化中起作用。
