Conde López V, Martínez Roig M
Area de Psiquiatría de la Facultad de Medicina, Universidad de Valladolid, España.
Actas Luso Esp Neurol Psiquiatr Cienc Afines. 1992 Jul-Aug;20(4):155-67.
The authors achieve a review of some clinical and therapeutic features related to the use of azaspirodecanodiones (buspirones, gepirone, ipsapirone). Buspirone--the only one available--is a novel nonbenzodiazepine anxiolytic that shows affinity for the serotonin 1A receptor subtype, acting as a partial agonist in the serotonergic system. This review attempts to put up to date the therapeutic studies of azaspirodecanodiones--especially buspirone--in anxiety (panic disorder, generalized anxiety disorder, obsessive-compulsive disorder), depression abuse and dependence of substances and other neuropsychiatric disorders. Though its main indication is generalized anxiety disorder, it may be also useful in treating other disorders and multiple psychopathologies related to serotonergic system dysfunctions, such as depression or alcoholism. Other interesting feature of buspirone is its potential usefulness in anxious elderly patients and long-term therapy.
作者对与氮杂螺癸二酮类药物（丁螺环酮、吉哌隆、伊沙匹隆）使用相关的一些临床和治疗特征进行了综述。丁螺环酮是唯一可用的此类药物，它是一种新型非苯二氮䓬类抗焦虑药，对5-羟色胺1A受体亚型具有亲和力，在5-羟色胺能系统中作为部分激动剂发挥作用。本综述试图更新氮杂螺癸二酮类药物——尤其是丁螺环酮——在焦虑症（惊恐障碍、广泛性焦虑症、强迫症）、物质滥用及依赖以及其他神经精神疾病方面的治疗研究。尽管其主要适应症是广泛性焦虑症，但它在治疗其他与5-羟色胺能系统功能障碍相关的疾病和多种精神病理状态（如抑郁症或酒精中毒）方面可能也有用处。丁螺环酮的另一个有趣特性是它在老年焦虑患者及长期治疗中的潜在用途。
