Yamada Y, Kakizaki K, Yamauchi H
Dept. of Surgery, Sendai National Hospital.
Gan To Kagaku Ryoho. 1992 Aug;19(10 Suppl):1713-5.
Portal blood levels of mitomycin C (MMC) were measured after intraperitoneal administration of 10 or 20 mg of mitomycin C following pancreatoduodenectomy. The portal concentration of MMC increased rapidly to the maximum concentration of 826 +/- 364 ng/ml at 5 minutes after administration, when the dosage was 20 mg (four cases). The peripheral blood levels followed the portal levels and the maximum concentration was 397 +/- 123 ng/ml at 15 minutes. Then the MMC levels of both portal and peripheral blood decreased gradually, but concentration higher than 100 ng/ml was maintained for 90 minutes after administration. In four patients given 10 mg of MMC, the patterns of the blood levels were similar, but the concentration was lower than in the group given 20 mg. In both groups, the AUC values were higher in portal than in peripheral blood. MMC administered intraperitoneally was absorbed rapidly through portal circulation and a high MMC level of portal blood was obtained. Therefore, it would prevent the dissemination of cancer cells into the liver which may well occur during operation for pancreatic carcinoma.
在胰十二指肠切除术后腹腔内给予10或20毫克丝裂霉素C（MMC）后，测定门静脉血中MMC的水平。当剂量为20毫克时（4例），给药后5分钟MMC的门静脉浓度迅速上升至最高浓度826±364纳克/毫升。外周血水平与门静脉水平一致，15分钟时最高浓度为397±123纳克/毫升。然后门静脉和外周血中的MMC水平逐渐下降，但给药后90分钟内浓度维持在100纳克/毫升以上。在给予10毫克MMC的4例患者中，血药浓度变化模式相似，但浓度低于给予20毫克的组。两组中，门静脉的AUC值均高于外周血。腹腔内给予的MMC通过门静脉循环迅速吸收，门静脉血中MMC水平较高。因此，这可以防止癌细胞在胰腺癌手术期间可能发生的肝内播散。
