Sato Y, Ohtsuka K, Ono K
Dept. of Surgery, Okayama Red Cross General Hospital.
Gan To Kagaku Ryoho. 1993 Jan;20(1):131-6.
Immediately before closing the abdomen in a curative operation for colorectal cancer, 20 mg of Mitomycin C (MMC) was administered by intravenous, intraperitoneal or intrapelvic routes, and portal blood and peripheral blood were simultaneously collected to investigate the disposition of MMC. After intravenous administration, the MMC concentration in portal and peripheral bloods changed at the same levels, showing a biphasic pattern. The maximum concentration (Cmax) seen shortly after administration was about 2 micrograms/ml. The blood halflife in phase alpha was about 5 min, and that in phase beta about 30 min. After intraperitoneal administration, the MMC concentration in portal blood was over 60 min higher than that in peripheral blood. Cmax in portal blood, seen within 5 min after administration, was about 0.5 micrograms/ml, and that in peripheral blood was about 0.2 micrograms/ml around 10 min. The half-life was about 30 min in both types of blood. After intrapelvic administration, the MMC concentration in portal blood changed at higher levels than in peripheral blood, as after intraperitoneal administration. The Cmax in portal blood, obtained within about 5 min, was about 0.3 micrograms/ml, and that in peripheral blood was about 0.1 micrograms/ml at 12 min. The half-life was about 30 min in both types of blood. As described above, the disposition of MMC was investigated on the basis of the concentration in portal and peripheral blood. As a result, intravenous MMC showed a similar change, whereas intraperitoneal or intrapelvic MMC was higher in portal blood than in peripheral blood, indicating that the disposition of MMC was different with the route of administration.
在对结直肠癌进行根治性手术即将关闭腹腔前，通过静脉、腹腔或盆腔内途径给予20毫克丝裂霉素C（MMC），并同时采集门静脉血和外周血以研究MMC的处置情况。静脉给药后，门静脉血和外周血中的MMC浓度以相同水平变化，呈现双相模式。给药后不久出现的最大浓度（Cmax）约为2微克/毫升。α相的血液半衰期约为5分钟，β相约为30分钟。腹腔给药后，门静脉血中的MMC浓度比外周血高60多分钟。给药后5分钟内门静脉血中的Cmax约为0.5微克/毫升，外周血中的Cmax在10分钟左右约为0.2微克/毫升。两种血液中的半衰期均约为30分钟。盆腔内给药后，门静脉血中的MMC浓度变化与腹腔给药后一样，高于外周血。给药后约5分钟获得的门静脉血中的Cmax约为0.3微克/毫升，外周血中的Cmax在12分钟时约为0.1微克/毫升。两种血液中的半衰期均约为30分钟。如上所述，根据门静脉血和外周血中的浓度对MMC的处置情况进行了研究。结果表明，静脉注射MMC呈现相似变化，而腹腔或盆腔内注射MMC时门静脉血中的浓度高于外周血，这表明MMC的处置情况因给药途径而异。
