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Beta-adrenoceptor antagonists enhance white blood cell aggregation in patients with ischaemic heart disease.β-肾上腺素能受体拮抗剂可增强缺血性心脏病患者的白细胞聚集。
Br J Clin Pharmacol. 1992 Sep;34(3):272-4. doi: 10.1111/j.1365-2125.1992.tb04137.x.
2
[Effect of nitrates, nitrate-like substances, calcium antagonists and beta-adrenergic receptor blockers on peripheral circulation].[硝酸盐、类硝酸盐物质、钙拮抗剂及β-肾上腺素能受体阻滞剂对周围循环的影响]
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Cardiovascular drugs and atherosclerosis: effects of calcium antagonists, beta-blockers, and nitrates on atherosclerotic characteristics of human aortic cells.心血管药物与动脉粥样硬化：钙拮抗剂、β受体阻滞剂及硝酸盐类对人主动脉细胞动脉粥样硬化特征的影响
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Beta-adrenergic receptors of human polymorphonuclear leukocytes.人多形核白细胞的β-肾上腺素能受体
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Diminished polymorphonuclear leukocyte adherence. Function dependent on release of cyclic AMP by endothelial cells after stimulation of beta-receptors by epinephrine.多形核白细胞黏附减少。该功能依赖于肾上腺素刺激β受体后内皮细胞释放环磷酸腺苷。
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White blood cell count and haematocrit as predictors of coronary recurrence after myocardial infarction.白细胞计数和血细胞比容作为心肌梗死后冠状动脉复发的预测指标。
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[Effect of isosorbide dinitrate on neutrophil migration in vivo].硝酸异山梨酯对体内中性粒细胞迁移的影响
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In vitro modulation of human neutrophil superoxide anion generation by various calcium channel antagonists used in ischemia-reperfusion resuscitation.用于缺血再灌注复苏的各种钙通道拮抗剂对人中性粒细胞超氧阴离子生成的体外调节作用。
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Neutrophil function in ischemic heart disease.缺血性心脏病中的中性粒细胞功能。
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β-肾上腺素能受体拮抗剂可增强缺血性心脏病患者的白细胞聚集。

Beta-adrenoceptor antagonists enhance white blood cell aggregation in patients with ischaemic heart disease.

作者信息

Bridges A B, Pringle T H, McNeill G P, Tavendale R, Belch J J

机构信息

University Department of Medicine, Ninewells Hospital and Medical School, Dundee.

出版信息

Br J Clin Pharmacol. 1992 Sep;34(3):272-4. doi: 10.1111/j.1365-2125.1992.tb04137.x.

DOI:10.1111/j.1365-2125.1992.tb04137.x
PMID:1356405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1381401/
Abstract

The effects of beta-adrenoceptor antagonists, calcium channel blockers and long acting nitrates on white blood cell (WBC) aggregation were studied in patients with ischaemic heart disease. WBC aggregation was significantly increased by beta-adrenoceptor antagonists (P = 0.011) but was unaffected by either calcium channel blockers or long acting nitrates. Enhanced WBC aggregation promotes microvascular occlusion and damage.

摘要

在缺血性心脏病患者中研究了β-肾上腺素能受体拮抗剂、钙通道阻滞剂和长效硝酸盐对白细胞（WBC）聚集的影响。β-肾上腺素能受体拮抗剂可显著增加白细胞聚集（P = 0.011），但钙通道阻滞剂或长效硝酸盐对其无影响。增强的白细胞聚集会促进微血管阻塞和损伤。