Tenniswood M P, Guenette R S, Lakins J, Mooibroek M, Wong P, Welsh J E
Department of Biochemistry, Faculty of Medicine, University of Ottawa, Ontario, Canada.
Cancer Metastasis Rev. 1992 Sep;11(2):197-220. doi: 10.1007/BF00048064.
Active cell death (ACD) in hormone-dependent tissues such as the prostate and mammary gland is readily induced by hormone ablation and by treatment with anti-androgens or anti-estrogens, calcium channel agonists and TGF beta. These agents induce a variety of genes within the hormone-dependent epithelial cells including TRPM-2, transglutaminase, poly(ADP-ribose) polymerase, Hsp27 and several other unidentified genes. Not all epithelial cells in the glands are equally sensitive to the induction of ACD. In the prostate, the secretory epithelial cells that are sensitive to hormone ablation are localized in the distal region of the prostatic ducts, and are in direct contact with the neighboring stroma. In contrast, the epithelial cells in the proximal regions of the ducts are more resistant to hormone ablation, probably because the permissive effects of the stroma are attenuated by the presence of the basal epithelial cells, which are intercalated between the epithelium and stroma. The underlying biology of ACD in prostate and mammary glands, and its relevance to hormone resistance, is discussed in this review.
在前列腺和乳腺等激素依赖性组织中，活性细胞死亡（ACD）很容易通过激素去除、抗雄激素或抗雌激素治疗、钙通道激动剂和转化生长因子β诱导产生。这些药物可诱导激素依赖性上皮细胞内的多种基因，包括瞬时受体电位阳离子通道蛋白M型2（TRPM-2）、转谷氨酰胺酶、聚（ADP-核糖）聚合酶、热休克蛋白27（Hsp27）以及其他几种未确定的基因。并非腺体内所有上皮细胞对ACD的诱导都同样敏感。在前列腺中，对激素去除敏感的分泌上皮细胞位于前列腺导管的远端区域，并且与相邻的基质直接接触。相比之下，导管近端区域的上皮细胞对激素去除更具抗性，这可能是因为基质的允许作用被位于上皮和基质之间的基底上皮细胞的存在所减弱。本文综述了前列腺和乳腺中ACD的潜在生物学特性及其与激素抵抗的相关性。
