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Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells.

作者信息

Caccamo A E, Scaltriti M, Caporali A, D'Arca D, Corti A, Corvetta D, Sala A, Bettuzzi S

出版信息

Cell Death Differ. 2005 Jan;12(1):101-4. doi: 10.1038/sj.cdd.4401491.

DOI:10.1038/sj.cdd.4401491
PMID:15499376
Abstract
摘要

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Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells.钙离子耗竭诱导核簇蛋白，这是永生化人前列腺细胞中一种新型的凋亡效应因子。
Cell Death Differ. 2005 Jan;12(1):101-4. doi: 10.1038/sj.cdd.4401491.
2
Intracellular clusterin induces G2-M phase arrest and cell death in PC-3 prostate cancer cells1.细胞内簇集素诱导PC-3前列腺癌细胞的G2-M期阻滞和细胞死亡1。
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Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression.聚集素（SGP-2）的瞬时过表达通过减缓细胞周期进程降低了SV40永生化人前列腺上皮细胞的增殖率。
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Cell detachment and apoptosis induction of immortalized human prostate epithelial cells are associated with early accumulation of a 45 kDa nuclear isoform of clusterin.永生化人前列腺上皮细胞的细胞脱离和凋亡诱导与簇集蛋白45 kDa核异构体的早期积累有关。
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Ectopic expression of clusterin/apolipoprotein J or Bcl-2 decreases the sensitivity of HaCaT cells to toxic effects of ropivacaine.簇集蛋白/载脂蛋白J或Bcl-2的异位表达降低了HaCaT细胞对罗哌卡因毒性作用的敏感性。
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Nuclear translocation of a clusterin isoform is associated with induction of anoikis in SV40-immortalized human prostate epithelial cells.一种簇集素亚型的核转位与SV40永生化人前列腺上皮细胞中失巢凋亡的诱导有关。
Ann N Y Acad Sci. 2003 Dec;1010:514-9. doi: 10.1196/annals.1299.095.
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Alterations in the post-translational modification and intracellular trafficking of clusterin in MCF-7 cells during apoptosis.MCF-7细胞凋亡过程中簇集蛋白翻译后修饰和细胞内运输的变化。
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Molecular mechanism of ursolic acid induced apoptosis in poorly differentiated endometrial cancer HEC108 cells.熊果酸诱导低分化子宫内膜癌HEC108细胞凋亡的分子机制
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Modulation of different clusterin isoforms in human colon tumorigenesis.人结肠癌发生过程中不同簇集素亚型的调控
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Clusterin is a Potential Therapeutic Target in Alzheimer's Disease.簇集蛋白是阿尔茨海默病的潜在治疗靶点。
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Yellow Chaste Weed and Its Components, Apigenin and Galangin, Affect Proliferation and Oxidative Stress in Blue Light-Irradiated HaCaT Cells.黄荆及其成分芹菜素和高良姜素影响蓝光照射 HaCaT 细胞的增殖和氧化应激。
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Effects of Calcium Oxalate on Expression of Clusterin and Lower Urinary Tract Symptoms in Prostatitis and Benign Prostatic Hyperplasia Patients with Calculi.草酸钙对前列腺炎和前列腺增生伴结石患者簇集蛋白表达及下尿路症状的影响。
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Amyloid-β breaks brain's neuroprotection.β-淀粉样蛋白破坏大脑的神经保护作用。
Oncotarget. 2017 Jul 25;8(30):48533. doi: 10.18632/oncotarget.18246.
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Exon-skipping strategy by ratio modulation between cytoprotective versus pro-apoptotic clusterin forms increased sensitivity of LNCaP to cell death.通过细胞保护性与促凋亡型簇蛋白比值调节的外显子跳跃策略，增加了 LNCaP 细胞对细胞死亡的敏感性。
PLoS One. 2013;8(2):e54920. doi: 10.1371/journal.pone.0054920. Epub 2013 Feb 13.
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