多巴胺能受体亚型对阴茎勃起的相反影响。

Opposite influences of dopaminergic receptor subtypes on penile erection.

Zarrindast M R, Shokravi S, Samini M

Department of Pharmacology, Medical Faculty, University of Tehran, Iran.

Gen Pharmacol. 1992 Jul;23(4):671-5. doi: 10.1016/0306-3623(92)90146-b.

Abstract

Mixed D-1/D-2 dopamine agonist apomorphine induced a penile erection (PE) in rats in a biphasic manner. 2. The response was decreased with increasing doses of the drug. 3. The maximum effect was obtained by 0.1 mg/kg of apomorphine. 4. In animals pretreated with D-1 antagonist SCH 23390, high doses of apomorphine showed higher PE response, while D-2 antagonist sulpiride pretreatment decreased the response of the low doses of the drug. 5. The inhibitory effect of sulpiride was dose-dependent. 6. The D-2 agonists bromocriptine or quinpirole induced a dose-dependent PE. 7. The effects of both drugs were decreased by sulpiride or SKF 38393 pretreatment. 8. Cholinergic drugs physostigmine and neostigmine did not induce PE, but antimuscarinic agent atropine decreased the effects of apomorphine, bromocriptine or quinpirole. 9. It is concluded that D-2 dopamine receptor stimulation may induce PE, while D-1 activation elicit an opposite effect. 10. However, cholinergic stimulation is not able to induce PE, cholinergic inhibition may decrease the PE induced by dopaminergic agents.

摘要

混合性D-1/D-2多巴胺激动剂阿扑吗啡以双相方式诱导大鼠阴茎勃起（PE）。2. 随着药物剂量增加，反应减弱。3. 0.1mg/kg阿扑吗啡可产生最大效应。4. 在预先用D-1拮抗剂SCH 23390处理的动物中，高剂量阿扑吗啡显示出更高的PE反应，而预先用D-2拮抗剂舒必利处理则降低了低剂量药物的反应。5. 舒必利的抑制作用呈剂量依赖性。6. D-2激动剂溴隐亭或喹吡罗诱导剂量依赖性的PE。7. 舒必利或SKF 38393预处理均可降低两种药物的作用。8. 胆碱能药物毒扁豆碱和新斯的明不诱导PE，但抗胆碱能药物阿托品可降低阿扑吗啡、溴隐亭或喹吡罗的作用。9. 得出结论：刺激D-2多巴胺受体可能诱导PE，而激活D-1则产生相反作用。10. 然而，胆碱能刺激不能诱导PE，胆碱能抑制可能降低多巴胺能药物诱导的PE。