多巴胺激动剂对完整小鼠和利血平处理小鼠运动的不同影响。

Differential effects of dopamine agonists on locomotion in intact and reserpine-treated mice.

Zarrindast M R, Eliassi A

Department of Pharmacology, Medical Faculty, University of Tehran, Iran.

Gen Pharmacol. 1991;22(6):1027-31. doi: 10.1016/0306-3623(91)90573-o.

Abstract

Apomorphine and bromocriptine induced a dose-dependent locomotion in mice. The responses of both drugs were decreased by SCH 23390 or sulpiride pretreatment. 2. Locomotor activity induced by apomorphine was increased and that of bromocriptine was decreased by reserpine. 3. SKF 38393 or quinpirole also induced locomotion. The response of SKF 38393 was decreased by reserpine. 4. Combination of SKF 38393 with bromocriptine induced a significant locomotor activity different from that of SKF 38393 or bromocriptine in reserpinized animals. 5. Combination of quinpirole with bromocriptine even decreased the response of bromocriptine in intact animals. 6. In conclusion, bromocriptine needs intact dopaminergic neurons and activation of D-1 receptor for expression of locomotion. High doses of quinpirole may induce locomotor activity possibly through D-1/D-2 receptor activation and quinpirole may potentiate the effect of bromocriptine on autoreceptor for inducing sedation.

摘要

阿扑吗啡和溴隐亭可诱导小鼠产生剂量依赖性运动。SCH 23390或舒必利预处理可降低两种药物的反应。2. 利血平可增加阿扑吗啡诱导的运动活性，降低溴隐亭诱导的运动活性。3. SKF 38393或喹吡罗也可诱导运动。利血平可降低SKF 38393的反应。4. 在利血平化的动物中，SKF 38393与溴隐亭联合使用可诱导出与SKF 38393或溴隐亭不同的显著运动活性。5. 在完整动物中，喹吡罗与溴隐亭联合使用甚至可降低溴隐亭的反应。6. 总之，溴隐亭需要完整的多巴胺能神经元和D-1受体激活才能表达运动活性。高剂量喹吡罗可能通过激活D-1/D-2受体诱导运动活性，喹吡罗可能增强溴隐亭对自身受体的作用以诱导镇静。