底物预处理对成年大鼠肾脏有机离子转运的影响。
Effect of substrate pretreatment on renal organic ion transport in the adult rat.
作者信息
Pegg D G, McCormack K M, Hook J B
出版信息
Experientia. 1976 Oct 15;32(10):1315-6. doi: 10.1007/BF01953113.
PMID:135696
Abstract
The ability of renal cortical slices to accumulate PAH and NMN was not significantly affected by pretreatment of adult rats with large doses of PAH. Pretreatment of adult rats with THAM significantly increased PAH accumulation but had no effect on NMN. Inulin and PAH clearance and filtration fraction were significantly decreased by PAH pretreatment but unaffected by THAM pretreatment. The effects of pretreatment on transport are probably due to non-specific toxicity.
摘要
大剂量对氨基马尿酸（PAH）预处理成年大鼠，并未显著影响肾皮质切片积累PAH和烟酰胺单核苷酸（NMN）的能力。三羟甲基氨基甲烷（THAM）预处理成年大鼠显著增加了PAH的积累，但对NMN没有影响。PAH预处理显著降低了菊粉和PAH清除率以及滤过分数，但THAM预处理未对其产生影响。预处理对转运的影响可能是由于非特异性毒性。
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