WILSON V J
J Gen Physiol. 1958 Sep 20;42(1):29-37. doi: 10.1085/jgp.42.1.29.
Meprobamate was administered intravenously to spinal cats, in cumulative doses of 30 to 40 mg./kg. each. Initial doses may have a variable action on monosynaptic reflexes. At times some reflexes are depressed, while others are enhanced or unaffected. When dose levels of 100 mg./kg. or higher are reached, monosynaptic reflexes, both flexor and extensor, are depressed. Monosynaptic reflexes can be strongly depressed by meprobamate, their input-output relations often remaining unchanged. In such cases there is thus no change in the spatial summation requirements of those motoneurons remaining in the excitable zone. Inhibitory pathways, both direct and disynaptic, are highly resistant to the action of meprobamate. The drug does not distinguish between the direct and disynaptic pathways. It is suggested that meprobamate acts as a general depressant of excitatory synaptic transmission.
将眠尔通以累积剂量30至40毫克/千克静脉注射给脊髓猫，每次注射的初始剂量对单突触反射可能有不同的作用。有时一些反射受到抑制，而其他反射则增强或不受影响。当达到100毫克/千克或更高的剂量水平时，屈肌和伸肌的单突触反射均受到抑制。眠尔通可强烈抑制单突触反射，其输入-输出关系通常保持不变。在这种情况下，处于兴奋区的那些运动神经元的空间总和需求没有变化。直接和双突触的抑制性通路对眠尔通的作用具有高度抗性。该药物无法区分直接和双突触通路。有人认为眠尔通作为兴奋性突触传递的一般抑制剂起作用。
